自身免疫性甲状腺疾病实验室诊断  

Laboratory diagnosis of Autoimmune thyroid diseases

作　　者：陈跃华[1] 孙桂云[1] 朱华芳[1] 李龙[1] 王竹红[1] 

机构地区：[1]江苏大学附属医院核医学科,江苏镇江212001

出　　处：《现代医药卫生》2006年第23期3353-3354,共2页Journal of Modern Medicine & Health

摘　　要：目的:采用TPOAb、TGb、FT3、FT4五项指标对自身免疫性甲状腺疾病(AITD)提供诊断和鉴别诊断的实验室依据。方法:采用放射免疫(受体)分析法测量165例AITD患者血清中TPOAb、TGAb、TRAb、FT3、FT4水平。结果:桥本甲状腺炎组TPOAb和TGAb升高与Graves病组、桥本甲亢组比较差异有显著性(P<0.001);TRAb、FT3、FT4正常与Graves病组、桥本甲亢组结果差异有显著性(P<0.001);Graves组和桥本甲亢组TRAb、FT3、FT4升高差异无显著性(P>0.05),而TPOAb和TGAb结果升高差异有显著性(P<0.001)。结论:上述五项实验室指标对AITD诊断、鉴别诊断及治疗原则、方法的选择具有重要意义。Objective： To evaluate the diagnostic information on autoimmune thyroid diseases （AITD） offered by the laboratorial indexes such as TPOAb, TRAb, FT3 and FT4. Methods： The concentrations of five indexes in 165 patients with AITD were measured by radioimmuneassay （RIA） and radioreceptorassay （RRA） and were contrasted and analyzed. Results： Compared with Grraves＇sisease group and Hashitoxicosis group, the levels increasd of TPOAb and TGAb in Hashimoto thyroiditis （HT） group were of significant difference （P〈0.001）, but low and significant in TRAb, FT3 and FT4. TPOAb and TGAb of Hashitoxicosis group were higher than those of Graves disease group （P〈0.001）, without distinction in FT3, FT4 and TRAb each other （P〉0.05）. Conclusion： Five laboratorial indexes mntioned, in highest measure, can greatly improve the reliability of diagnosis on AITD, helping the choice of a optimal therapy.

关 键 词：GRAVES病 桥本甲关腺炎 桥本甲亢 实验室诊断 

分 类 号：R445[医药卫生—影像医学与核医学]