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机构地区:[1]郑州市解放军153中心医院感染病科,450042
出 处:《实用肝脏病杂志》2006年第6期325-327,共3页Journal of Practical Hepatology
基 金:河南省科委科研基金资助项目No96031
摘 要:目的探索活血化淤中药对脂肪肝肝纤维化发生的干预作用,尤其是对肝组织TIMP-1和TIMP-2蛋白表达的影响。方法用免疫组化法分别测定15例脂肪性肝炎患者治疗前后肝组织TIMP-1和TIMP-2蛋白的表达。结果活血化淤药物治疗后TIMP-1和TIMP-2表达水平明显低于治疗前。对照组肝组织TIMP-1、TIMP-2表达水平无明显变化。结论TIMP-1、TIMP-2与肝纤维化形成密切相关,活血化淤中药治疗对脂肪肝患者肝内TIMP-1和TIMP-2蛋白的表达有一定的抑制作用。Objective To investigate the effect of Chinese herbal medicine on tissue inhibitor of metalloproteinase (TIMP2 and TIMP-1) in patients with hepatic steatosis, because these enzymes participate in the degradation of the extracellular matrix including the basement membrane. Method Normal and hepatic fibrosis liver samples were obtained from hepatic steatosis patients after they received herbal medicine for three months. The TIMP-1 and TIMP2 were detected in the liver tissues by immunohistochemical examinations. Results In 5 of 12 samples showed stronger expression of TIMP-1 and TIMP-2 in the liver tissues than in the normal tissues; TIMP2 was detected in 9 of the 12cases. Irnmunohistochemical examinations revealed that TIMP-1 was obvious in hepatic steatosis patients. Conclusion The study shows that TIMP-1 and TIMP-2 participates in hepatic fibrosis in steatosis. The herbal medicine can downregulate the expression of TIMP-1 and TIMP-2 .
关 键 词:脂肪性肝炎 活血化淤中药 金属蛋白酶组织抑制因予
分 类 号:R259[医药卫生—中西医结合]
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