不同剂量长效抑那通在体外受精-胚胎移植中的治疗效果观察  

The application of low dose Enantone in IVF-ET

作　　者：胡咏华[1] 徐键[1] 吴丽萍[1] 

机构地区：[1]浙江大学医学院附属妇产科医院,杭州310006

出　　处：《浙江医学》2006年第11期892-895,共4页Zhejiang Medical Journal

摘　　要：目的探讨在体外受精-胚胎移植(IVF-ET)中,减少长效促性腺激素释放激素激动剂的剂量是否能达到更好的治疗效果。方法对56例接受IVF-ET的助孕者随机分组,A组(28例)接受小剂量的抑那通(2mg);B组(28例)接受常规剂量的抑那通(3.75mg)。结果A组在使用促性腺激素(Gn)前的黄体生成素(LH)水平为(1.85±1.03)IU/L,显著高于B组的(1.30±0.81)IU/L(t=2.225,P<0.05),但A、B两组在绒毛膜促性腺激素(HCG)注射日的LH水平分别为(0.67±0.46)IU/L、(0.78±0.35)IU/L,两组比较差异无统计学意义(t′=0.932,P>0.05)。两组均无内源性LH峰出现。A组在使用Gn前及HCG注射日的雌二醇(E2)水平分别为(87.66±20.35)pmol/L、(13312.83±8933.87)pmol/L,B组分别为(77.37±15.66)pmol/L、(10481.63±8588.19)pmol/L,两组比较差异无统计学意义(P>0.05);A组Gn用量及用药天数分别为(31.96±7.39)支、(12.57±2.62)d,B组为(29.50±5.57)支、(11.68±2.13)d,两组比较差异无统计学意义(均P>0.05);A组的获卵数、受精率、卵裂率、周期妊娠率、移植妊娠率、流产率、种植率分别为(16.00±7.04)个、69.87%、91.69%、60.71%、62.96%、11.76%、23.26%,B组分别为(14.14±7.27)个、72.22%、89.51%、39.29%、45.83%、18.18%、17.11%,两组比较差异均无统计学意义(均P>0.05)。结论小剂量的抑那通即能获得与常规剂量抑那通相同的治疗效果。Objective To evaluate the application of long-acting gonadotrophin-releasing hormone analogue （GnRH-a） enantone with low dose for in vitro fertilization-embryo transfer （IVF-ET）. Methods Fifty six patients undergoing IVF-ET were randomly divided into group A （28 cycles） who received a low dose of enantone （2mg） and group B （28 cycles） who received conventional dose of enantone （3.75mg）. Results The serum luteinizing hormore （LH） level before use of gonadotrophin （Gn） in group A was （1.85 ± 1.03）IU/L and that of group B was （1.30 ± 0.81）IU/L （t＇ =2.225, P 〈 0.05）, but there was no significant differences in LH level on the day of human chorionic gunadotropin （HCG） administration between two groups （0.67 ± 0.46）IU/L vs （0.78 ± 0.35）IU/L （t＇ =0.932, P〉0.05）. There was no spontaneous premature LH surge in two groups. There were no significant differences between two groups either in the serum oestradiol （E2） level before use of Gn and on the day of HCG administration, days of Gn stimulation, nor in the number of eecytes retrieved, fertilization rate, embryo cleaved rate, pregnancy rate/cycle, pregnancy rate/transfer, misearrige rate and implantation rate （all P〉0.05）. Conclusion The use of low dose enantone appears to be equally effective with the conventional dose in IVF-ET.

关 键 词：体外受精-胚胎移植 促性腺激素释放激素激动剂 控制性超排卵 垂体降调节 抑那通 

分 类 号：R714.8[医药卫生—妇产科学]