子痫前期患者母胎循环肝细胞生长因子检测及其意义  

Measurement of maternal and fetal circulating hepatocyte growth factor(HGF) in preeclampsia

作　　者：符孜牧[1] 吕时铭[1] 

机构地区：[1]浙江大学医学院附属妇产科医院

出　　处：《浙江医学》2006年第11期899-900,911,共3页Zhejiang Medical Journal

基　　金：绍兴市科技计划项目资助(2004137)

摘　　要：目的探讨子痫前期母胎循环肝细胞生长因子(HGF)对子痫前期发病的影响。方法采用酶联免疫吸附法测定33例子痫前期孕妇(子痫前期组)和32例正常妊娠孕妇(对照组)外周血、脐静脉血清HGF水平。结果子痫前期组孕妇外周血HGF水平为(142.9±87.64)pg/ml,明显低于对照组的(207.6±110.55)pg/ml(t=2.487,P<0.05);子痫前期组孕妇脐静脉血HGF水平为(13.2±6.28)pg/ml,与正常对照组(16.5±8.22)pg/ml比较差异无统计学意义(t=1.546,P>0.05)。轻度和重度子痫前期孕妇外周血、脐静脉血HGF水平差异均无显著性意义(t=0.382、0.747,均P>0.05)。结论外周血HGF下降可能是子痫前期重要的发病机制之一。Objective To investigate the changes of hepatocyte growth factor（ HGF）in maternal and fetal circulalion of patients with preeclampsia. Methods The concentration of maternal and fetal circulating HGF in 33 preeclampsia patients （PE group） and 32 normal pregnancies （control group） were, assessed by enzyme-linked immunosorbent assay （ELISA）. Results The HGF levels in peripheral serum of PE group [（142.9 ±87.64）pg/ml] were significantly lower than those in controls [（207.6 ± 110.55）pg/ml] （P〈0.05）. The differences in fetal circulating HGF levels between two groups were not significant [（1 3.2 ± 6.28）pg/ml and （ 16.5 ± 8.22 ）pg/ml rspectively]（P〉0.05）. Both in mild and severe preeclampsia, the concentrations of HGF in maternal and fetal circulation had no significant differences （P〉0.05）. Conclusions The levels of maternal circulating HGF are dereased in disease of Preeclampsia, which suggests that HGF may have important role in pathogenesis of preeclampsia.

关 键 词：肝细胞生长因子 子痫前期 妊娠并发症 心血管 高血压 

分 类 号：R714.2[医药卫生—妇产科学]