香草醛／环糊精包合性能研究  

Study on the inclusion complex of vanillin/cyclodextrin

作　　者：高剑锋[1] 任勇[1] 王晓洁[1] 

机构地区：[1]南京师范大学新药研究中心,南京210097

出　　处：《中国新药杂志》2006年第21期1858-1861,共4页Chinese Journal of New Drugs

摘　　要：目的:研究环糊精对香草醛的包合性能。方法:采用紫外分光光度法研究香草醛／环糊精包合作用;研磨法制备包合物;差示热分析和1H-NMR验证包合物;紫外分光光度法考察包合物的溶解度;影响因素实验和加速实验验证包合物的稳定性。结果:香草醛与环糊精可形成1:1的稳定包合物,包合常数为1 063-13 793 L·mol-1,37℃下包合物使香草醛的溶解度增加14．43倍,包合物稳定性大大增强。结论:环糊精能明显增加香草醛溶解度、增强其稳定性,该技术对香草醛制剂的改进具有应用价值。Objective：To study the inclusion complex of vanillin and cyclodextrin. Methods：The inclusion complex of vanillin and β-cyclodextrin was prepared by levigation, characterized by ultraviolet spectroscopy and validated by DTA, XRD and ^1H-NMR. The stability of the inclusion complex was tested in the acceleration test setting. Results：The inclusion complex had a molar ratio of vanillin to cyclodextrin of 1：1 and the inclusion constant of 1 063 - 13 793 L·mol^-1.. The inclusion complex made at 37℃ increased the solubility of vanillin by 14.43 times and showed improved stability. Conclusion：The improvement of the solubility and stability of vanillin by β-cyclodextrin may enhance medical values of vanillin preparation.

关 键 词：香草醛 环糊精 包合比 包合常数 溶解度 稳定性 

分 类 号：R943.5[医药卫生—药剂学] R971.6[医药卫生—药学]