挤出滚圆法制备复方杞芪微丸的处方及工艺优化  

Formulation and process optimization of formula Qiqi pellets prepared by extrusion-spheronization

作　　者：陈红霞[1] 贾晓斌[1] 陈彦[2] 潘国梁[2] 成旭东[2] 

机构地区：[1]江苏大学药学院,江苏镇江212001 [2]江苏省中医药研究院,江苏南京210028

出　　处：《中国中药杂志》2006年第22期1862-1865,共4页China Journal of Chinese Materia Medica

基　　金：江苏省135工程重点人才资助项目(65RC2002065)

摘　　要：目的:应用挤出滚圆法制备中药复方杞芪微丸,研究微丸制备的最佳处方和工艺。方法:用新型的挤出滚圆造粒机制备复方杞芪微丸;采用单因素考察和正交设计筛选最优处方和工艺条件;考察了微丸的粉体学性质和收率。结果:用挤出滚圆法制备的杞芪微丸圆整度好,大小均匀,成品收率高。结论:用国产的挤出滚圆造粒机可以制备中药微丸。该工艺简便易行,制得的微丸质量好,值得进一步研究。Objective：To prepare traditional Chinese medicine formula Qiqi pellets by extrusion-spheronization and study the optimal formulation and process. Method：Qiqi pellets were prepared by a new style extrusion-spheronization equipment, the optimal formulation and process was obtained by the studies of influenitial factors and L9 （ 3^4 ） orthogonal design, the micromeritic properties and product yield of pellets were determined. Result： The formula Qiqi pellets prepared by extrusion-spheronization were all spheral with smooth surface; the product yield was high. Conclusion： Extrusion-spheronization was suitable to produce Chinese Herbal Medicine pellets. The preparation process was simple and feasible ; The quality of the prepared pellets was excellent. It was worth further study.

关 键 词：杞芪复方 挤出滚圆法 微丸 粉体学性质 收率 

分 类 号：TQ461[化学工程—制药化工]