鹿角方改善充血性心力衰竭患者左心室肥厚程度的效应(英文)  

Effect of Lujiao prescription on the degree of left ventricular hypertrophy in patients with congestive heart failure

作　　者：蔡辉[1] 胡婉英[2] 王艳君[3] 郭郡浩[1] 胡兵[1] 张俊慧[1] 

机构地区：[1]解放军南京军区南京总医院中西医结合科,江苏省南京市210002 [2]上海中医药大学附属曙光医院,上海市200021 [3]河北医科大学博士后流动站,河北省石家庄市050017

出　　处：《中国临床康复》2006年第43期222-224,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:左心室肥厚是充血性心力衰竭发生发展的主要环节,作为心血管疾病的独立危险因子已形成共识,如何逆转或减轻左心室肥厚对于改善心功能防治充血性心力衰竭具有重要的临床价值。目的:观察鹿角方对充血性心力衰竭患者左心室肥厚程度的影响。设计:以充血性心力衰竭患者为观察对象的随机对照观察。单位:上海中医药大学附属曙光医院心血管内科。对象:选择1996-01/1998-12上海中医药大学附属曙光医院心血管内科病房及专科门诊的充血性心力衰竭患者20例,纳入标准:①符合Framinham心衰诊断标准。②纽约心脏病学会心功能Ⅲ级以上。③病史3个月以上。④接受适量的利尿剂或扩血管药物(血管紧张素转换酶抑制剂(ACEI)除外)作基础治疗。⑤胸部X射线片及超声心动图有左心室扩大的证据。所有患者均对治疗项目知情同意。方法:将所有患者抽签法随机分为鹿角方组和地高辛组,每组10例。①给予鹿角方组患者口服上海曙光医院按既定工艺研制的鹿角方口服液35mL,2次/d,3个月为1疗程。地高辛组患者同时口服杭州民生药厂生产的地高辛片(0.25mg/片,批号970757),0.125～0.25mg,1次/d,3个月为1疗程。①治疗后分别观察两组患者纽约心脏病学会心功能分级。②超声心动图检查分别测量患者舒张期室间隔厚度、舒张期左室后壁厚度。根据Devereux公式计算左心室心肌重量,并用体表面积矫正计算左心室重量指数。参考Devereux标准判断左心室肥厚程度。③对两组患者血浆血管紧张素Ⅱ放免测定。主要观察指标:两组患者纽约心脏病学会心功能分级、超声心动图(室间隔厚度、左心室后壁厚度、左心室重量指数、左心室肥厚程度)及血浆血管紧张素Ⅱ水平。结果:纳入患者20例,全部进入结果分析。①鹿角方组患者治疗后纽约心脏病学会心功能分级Ⅰ,Ⅱ,Ⅲ,Ⅳ级分别为2,5,3,BACKGROUND： Left ventrieular hypertrophy （LVH） is an important ring-jolnt of congestive heart failure （CHF）. It is also considered to be independent risk factor of cardiovascular disease, so how to reverse or relieve LYH is valuable to cure CHF. OBJECTIVE： To observe the effect of Lujiao prescription on degree of LVH in patients with CHF. DESIGN： A random-control observation on CHF patients. SETTING： Department of Cardiovasology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. PARTICIPANTS： A total of 20 patients with CHF were selected from the Special Clinic and Department of Cardiovasology in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 1996 to December 1998. All of them were consistent with the Framinham diagnostic criteria and following standardizations： （1）above Ⅲ degree of cardiac functional grading by New York Heart Association （NYHA）;（2） over 3 months case history;（3）accepted basic treatment of quantity sufficient diuretic and vasodilating agent excluding angiotensin converting enzyme inhibitor （ACEI）;LVH was proved by echocardiogram or chest X-ray. They were informed of treatment items and consented. METHODS： According to random lot, the patients were divided into Lujiao prescription group and Digoxin group, each containing 10 patients.（1） Oral administrations of Lujiao prescription （35 mL, two times per day, produced by Shanghai Shuguang Hospital） and Digoxin （0.125-0.25 mg per tablet, batch number： 970757, once daily） were given in the corresponding groups, and the treatment duration was 3 months. After treatment, all the patients were detected in（1）NYHA cardiac functional grading; （2）interventricular septal thickness （IVST） and posterior wall thickness （PWT） in diastolic phase through echocardiogram, myocardium weight of left ventricular by Devereux formula, left ventricular mass index （LVMI） corrected by body surface area, and de

关 键 词：充血性心力衰竭 左室肥厚 鹿角方 

分 类 号：R541.61[医药卫生—心血管疾病]