坏死梭杆菌病免疫学研究进展  

Development of Immunological Study on Fusobacterium nerophorum Infections

作　　者：苗利光[1] 杨福合[1] 刘艳环[1] 王志刚[1] 

机构地区：[1]中国农业科学院特产研究所,吉林吉林132109

出　　处：《动物医学进展》2006年第11期22-25,共4页Progress In Veterinary Medicine

基　　金：中国农业科学院特产研究所科研基金项目(tcs-20041);国家科技部奶牛专项基金(2002BA518A04)

摘　　要：长期以来,国内外研究人员一直致力于坏死梭杆菌的免疫性及免疫作用研究,但进展缓慢,主要原因是坏死梭杆菌免疫作用弱,无法产生保护性免疫。直到20世纪80年代末,对坏死梭杆菌免疫研究才有了新的突破,初步研制出坏死梭杆菌疫苗,并经小群动物试验获得成功。文章就坏死梭杆菌免疫性及免疫作用的初始研究、坏死梭杆菌免疫原筛选研究、抗原间的相互作用、疫苗研究进展进行了综述,并展望了坏死梭杆菌疫苗研究的发展趋势。The immunity and immune effect of Fusobacterium nerophorum have been researched, but just tew successes had been got. The primary reason is that the weak immunogenicity can not provide effective protection. By the late twentieth century,because the immunological study on Fusobacterium nerophorum got significant progress,the Fusobacterium nerophorum vaccine was prepared and provided effective profection in small groups of animals. This paper described the early studies of the immunity and immune effect, immunogen screening of Fusobacterium nerophorum, reaction of antibodies and development of vaccine studies,and indicated the prospect of Fusobacterium nerophorum vaccine.

关 键 词：坏死梭杆菌 免疫 疫苗 

分 类 号：S852.616.3[农业科学—基础兽医学]