病理性瘢痕组织中基质金属蛋白酶-1、金属蛋白酶组织抑制剂-1、血小板源性生长因子、增殖细胞核抗原的表达  

Expression of matrix metalloproteinase-1,tissue inhibitor of metalloproteinase-1,platelet-derived growth factor, and proliferating cell nuclear antigen in pathologic scar tissue

作　　者：郭丽丽[1] 陈言汤[1] 牛扶幼[1] 刘林嶓[1] 

机构地区：[1]郑州大学第一附属医院整形外科,河南省高等学校临床医学重点学科开放实验室,郑州450052

出　　处：《郑州大学学报（医学版）》2006年第6期1027-1030,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省科技攻关基金资助项目971901300

摘　　要：目的探讨病理性瘢痕组织中基质金属蛋白酶-1(MMP-1)、金属蛋白酶组织抑制剂-1(TIMP-1)、血小板源性生长因子(PDGF)、增殖细胞核抗原(PCNA)的表达及意义。方法采用免疫组织化学方法检测58例病理性瘢痕、16例正常皮肤及16例非病理性瘢痕组织中MMP-1、TIMP-1、PDGF及PCNA的表达情况。结果病理性瘢痕组织中MMP-1、TIMP-1、PDGF阳性表达率及PCNA指数均高于非病理性瘢痕及正常皮肤组织(P均<0.05)。病理性瘢痕组织中TIMP-1与PDGF、MMP-1、PCNA及PDGF与PCNA表达均呈正相关(P均<0.05)。结论病理性瘢痕的形成与MMP-1、TIMP-1、PDGF及PCNA相互作用失衡有关。To study the expression of matrix metalloproteinase-1 （ MMP-1 ） , tissue inhibitor of metalloproteinase-1 （TIMP-1）, platelet-derived growth factor （PDGF） , and proliferating cell nuclear antigen （PCNA） in pathologic scar. Methods： The expressions of MMP-1, TIMP-1 , PDGF, and PCNA were detected using immunohistochemistry in 58 cases of pathologic scar, 16 cases of normal skin, and 16 cases of normotrophic scar. Results： The positive rates of MMP-1, TIMP-1, and PDGF and the proliferation index of PCNA in pathologic scar were higher than those in normal skin and normotrophic scar （P 〈0.05）. There were positive correlation between TIMP-1 and PDGF, TIMP-1 and MMP-1 , TIMP-1 and PCNA, PDGF and PCN A （P 〈 0.05）, Conclusion： The formation of pathologic scar is correlated with the imbalance of interaction among MMP-1 , TIMP-1, PDGF, and PCNA,

关 键 词：增生性瘢痕 瘢痕疙瘩 基质金属蛋白酶-1 金属蛋白酶组织抑制剂-1 血小板源性生长因子 增殖 细胞核抗原 

分 类 号：R622[医药卫生—整形外科]