病理性瘢痕组织中Survivin、P33ING1、Caspase-3蛋白的表达  

Expression of Survivin, P33ING1, and Caspase-3 proteins in pathologic scar tissue

作　　者：伍成奇[1,2] 刘林嶓[1] 李珊珊[3] 陈言汤[1] 牛扶幼[1] 郝媛媛[1] 

机构地区：[1]郑州大学第一附属医院整形外科,河南省高等学校临床医学重点学科开放实验室 [2]南阳市中心医院整形外科,南阳473000 [3]郑州大学基础医学院病理学教研室

出　　处：《郑州大学学报（医学版）》2006年第6期1038-1041,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省科技攻关基金资助项目971901300

摘　　要：目的检测病理性瘢痕组织中Survivin、P33ING1、Caspase-3蛋白的表达情况。方法采用免疫组织化学方法检测30例病理性瘢痕组织、10例非病理性瘢痕和20例正常皮肤组织中Survivin、P33ING1、Caspase-3的表达情况。结果病理性瘢痕、非病理性瘢痕和正常皮肤组织中Survivin、P33ING1和Caspase-3的阳性表达率分别为80.0%、50.0%、35.0%,43.3%、70.0%、85.0%和30.0%、80.0%、90.0%;病理性瘢痕组织与非病理性瘢痕和正常皮肤组织比较,3指标差异均有统计学意义(P<0.05)。病理性瘢痕组织中Caspase-3与Survivin(r=-0.400)和P33ING1(r=0.602)表达均具有相关性(P<0.05)。结论Survivin的高表达与Caspase-3和P33ING1的表达下调在病理性瘢痕的形成中可能起协同作用。Aim： To investigate the expressions of apoptosis-related Survivin, P33ING1, and Caspase-3 in pathologic scar formation. Methods： The expressions of Survivin, P33ING1, and Caspase-3 in 30 cases of pathologic scar, 10 cases of non-pathologic scars, and 20 cases of normal skin tissue were detected using immunohistochemical methods, Results： The positive rates of survivin, P33ING1, and Caspase-3 in pathologic scar, non-pathologic scar, and normal skin tissue were 80.0% ,50.0% ,35.0% ,43, 3% ,70.0% ,85.0% and 30.0% ,80.0% ,90.0% , respectively, Compared with non- pathologic scar and normal skin cases, the expressions of Survivin, P33ING1 , and Caspase-3 had significant difference in pathologic scar cases（P 〈 0.05）. Caspase-3 expression were correlated with Survivin （ r = - 0. 400 ） and P33ING1 （ r - 0.602） in pathologic scar tissue （P 〈 0. 05 ）. Conclusion： The uverexpression of Survivin and down-regulation of Caspase-3 and P33ING1 expressions may play a coordinated role in pathologic scars.

关 键 词：增生性瘢痕 瘢痕疙瘩 SURVIVIN P33ING1 CASPASE-3 

分 类 号：R622[医药卫生—整形外科]