成人HIV/AIDS患者CD_4^+T淋巴细胞与淋巴细胞总数的关系及其意义  

Relationship and Significance of CD^+_4T Cells and Total Lymphocytes in Adult HIV/AIDS Patients

作　　者：王景泉[1] 沈成利[1] 郭彩萍[1] 梁连春[1] 吴昊[1] 

机构地区：[1]首都医科大学附属北京佑安医院感染科,北京市100069

出　　处：《中国全科医学》2006年第22期1859-1861,共3页Chinese General Practice

摘　　要：目的探讨HIV/AIDS患者CD4+T淋巴细胞绝对计数与血清淋巴细胞总数的关系及其临床意义。方法使用美国BD公司FACSCalibur流式细胞仪对CD4+T淋巴细胞绝对值进行测定,并根据外周血CD4+T淋巴细胞计数将淋巴细胞总数分为3类,以对应不同的CD4+T淋巴细胞计数范围。建立两者间的回归方程,同时绘制ROC曲线,总结三种用外周血淋巴细胞预测CD4+T淋巴细胞绝对值的方法。结果经决策树分析,对应3类淋巴细胞界值数的CD4+T淋巴细胞预测数分别为62个/μl、177个/μl和354个/μl;经相关性分析,非线性回归二者间相关系数为0·635,直线相关性回归二者间相关系数为0·607;经ROC曲线分析,针对CD4+T淋巴细胞数<50个/μl、100个/μl、200个/μl、350个/μl求得的曲线下面积分别为0·831、0·830、0·816和0·780。结论采用外周血淋巴细胞计数作为患者CD4+T淋巴细胞数的替代指标,对资源有限地区评估疾病病情和指导临床治疗有一定的参考价值,值得推广。Objective To study the relationship and clinical significance of CD; T cells and total lymphocytes in adult HIV/AIDS patients. Methods The absolute CD4^＋T cells count was analyzed by FACS flow cytometer from BD company, thc total lymphocytes were classified into three species according to the distribution of peripheral blood CD4^＋ T cells, then the regression equation was built, finally, the ROC curve was drawn. Results The predicted CD; T cells for the three node of lymphocytes were 62 cells/μl, 177 cells/μl and 354 cells/μl respectively; using regression analysis, by non linear regression, the correlation coefficient was 0. 635, by linear regression was 0. 607 ; by ROC analysis, the area below the curve for CD; T lymphocytes under 50 cells/μl, 100 cells/μl, 200 cells/μl and 350 cells/μl were 0. 831, 0. 830, 0. 816 and 0. 780 respectively. Conclusion Total lymphocytes counting used as predictive marker instead of CD4^＋ T cells has some value to evaluate the patients＇ condition and guide the clinical treatment, which is worth spreading widely.

关 键 词：HIV/AIDS CD4^+ 淋巴细胞总数 

分 类 号：R512.91[医药卫生—内科学]