正常高值血压人群10年心血管病发病危险的分析  

The 10-year cardiovascular risk in a Chinese cohort aged 35-64 years with high-normal blood pressure

作　　者：赵冬[1] 李翠芬[1] 王薇[1] 刘静[1] 曾哲淳[1] 王文化[1] 孙佳艺[1] 吴兆苏[1] 

机构地区：[1]首都医科大学附属北京安贞医院北京市心肺血管疾病研究所,北京100029

出　　处：《中华老年心脑血管病杂志》2006年第11期730-733,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金："八五"国家科技攻关课题(85-915-01-02);北京心血管病高技术实验室资助项目(953850700)

摘　　要：目的探讨中国35-64岁人群正常高值血压（采用2005年中国高血压指南新的定义）的分布特点、与其他心血管病危险因素的关系及10年心血管病发病危险。方法采用前瞻性队列研究，对1992年建立的11省市35-64岁队列研究共30378人基线时血压水平、心血管病危险因素分布及10年发生心脑血管病事件（包括冠心病和脑卒中）危险关系进行分析。结果（1）中国35-64岁人群中正常高值血压的现患率为32．2％，其中男性为34．2％，女性为30．2％。（2）正常高值血压人群，收缩压和舒张压均在正常高值范围者最多（45．0％），其次为仅收缩压在正常高值范围者（34．9％），舒张压在正常高值者最少（20．1％）。（3）正常高值血压人群的心血管病危险因素平均水平高于正常血压人群。（4）调整年龄、性别和其他心血管病危险因素后，与正常血压者相比，基线血压在正常高值范围者10年冠心病事件的发病风险增加31％，脑卒中事件的发病风险增加49％，总心血管病事件的发病风险增加44％。结论正常高值血压者心血管病发病危险高于正常血压者，应加强正常高值血压人群高血压及心脑血管事件的早期防治。Objective To explore the distribution of the high-normal blood pressure（BP）, and the association between high-normal blood pressure and cardiovascular risk in a Chinese cohort aged 35-64 years.Methods A prospective study was carried out in 11 provinces from 1992 to 2002. The association between baseline BP, cardiovascular risk factors and CVD （CHD and stroke） was analyzed in 30378 subjects aged 35-64 years. Results （1） The age standardized prevalence rate of high-normal BP was 32.2% in this population. The rate in males （34.2%） was significantly higher than that in females （30.2%）. （2） In high-normal BP group, sub- jects with both SBP and DBP at high-normal BP level accounted for the majority （45 % ）, subjects with only DBP at high-normal BP level had the lowest prevalence rate （20.1% ）. This trend was even more obvious with increasing age. （3） Compared with normal BP subjects, the high-normal BP subjects had higher level of card- iovascular risk factors. （4） After adjusting for age, sex, and other cardiovascular risk factors, the risk of CVD in subjects with high-normal BP increased by 49%, whereas the risk of stroke and CI-ID increased by 31% and 44% as compared with normal BP subjects, respectively. Conclusion The high-normal BP person had higher risk of CVD than normal person, the prevention and control of hypertension and CVD of this group should be enhanced.

关 键 词：高血压 心血管疾病 危险因素 发病率 

分 类 号：R54[医药卫生—心血管疾病]