缬沙坦对老年高血压患者P波离散度的影响及临床意义  

Effects of valsartan on P-wave dispersion in elderly patients with essential hypertension

作　　者：盖晓波[1] 黄明方[1] 侯建萍[1] 李刚[1] 张慧敏[1] 林文珍[1] 

机构地区：[1]南京军区福州总医院心内科,福建福州350025

出　　处：《中华老年心脑血管病杂志》2006年第11期738-740,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的比较缬沙坦和氨氯地平对老年高血压患者P波离散度的影响。方法将68例年龄60岁以上的老年原发性轻中度（1～2级）高血压患者，随机分为实验组（34例）和对照组（34例），分别接受16周的缬沙坦和氨氯地平治疗。治疗期间监测血压，分别于治疗前和治疗16周后检测心电图和超声心动图。结果两组患者在用药后，血压（P〈0．001）和左心室重量指数（P〈0．05）均明显下降，下降程度无显著性差异；治疗后，两组患者P波离散度和P波最大时限均显著降低，实验组比对照组降低明显。结论缬沙坦和氨氯地平均能有效降压、逆转左心室肥厚，降低P波离散度，在同等降压条件下，缬沙坦能进一步降低P波离散度和P波最大时限。Objective To compare the effects of valsartan and amlodipine on P-wave dispersion（Pd） after 16-week treatment in elderly patients with essential hypertension. Methods Sixty-eight elderly mild to moderate hypertensive patients with sinus rhythm were randomly assigned to two groups of 34 patients each. The test group and control group took valsartan and amlodipine, respectively. Clinical blood pressure was evaluated every day, 12-lead surface electrocardiograms were taken and left atrial diameter was measured by echocardiography before and after 16-week drug therapy. Results Compared with the baseline, the post-treatment values of systolic blood pressure （ P 〈 0. 001 ）, diastolic blood pressure （ P 〈 0. 001 ）, and left ventricular mass index （ P 〈 0.05） were significantly decreased in both groups and the extents of decrease were similar between two groups. After 16-week treatment, the maximum P-wave duration （Pmax） and Pd were significantly decreased in both groups （ P 〈 0.001）,and the decrease was more marked in test group than in control group（ P 〈0.01 for Pmax; P 〈0.05 for Pd）. Condusions Both valsartan and amlodipine are effective drugs to reduce blood pressure, reverse left ventricular hypertrophy, and cause similar blood pressure reduction. Valsartan has much greater lowering effect on Pmax and Pd values than amlodipine.

关 键 词：缬沙坦 氨氯地平 高血压 心房颤动 

分 类 号：R544.1[医药卫生—心血管疾病]