正弦偏心旋转诱发的豚鼠前庭眼动反射特点  

CHARACTERISTICS OF VESTIBULAR-OCULAR REFLEX IN GUINEA PIGS DURING ECCENTRIC SINUSOIDAL ROTATION

作　　者：贾宏博[1] 毕红哲[1] 刘广莉[1] 谢溯江[1] 王锦铃[2] 田大卫[1] 王善详[1] 

机构地区：[1]空军航空医学研究所,北京100036 [2]第四军医大学西京医院耳鼻喉科,陕西西安710032

出　　处：《中国应用生理学杂志》2006年第4期501-504,共4页Chinese Journal of Applied Physiology

摘　　要：目的:观察豚鼠于不同频率和偏心半径正弦旋转时相对于轴心旋转的前庭眼动反射变化特点,以提取反映前庭耳石器功能的指标,为建立其功能检测方法提供依据。方法:采用频率0.1,0.2,0.3,0.4,0.5,0.6Hz,峰速60°/s的正弦旋转刺激,分别将豚鼠置于轴心,头向外偏心半径330mm,660mm,990mm处诱发其眼震,分析不同刺激条件下的眼震增益变化规律。结果:频率和偏心半径都对眼震的增益有显著影响:同一偏心半径条件下,眼震增益随频率增加而增大;同一频率条件下,眼震增益随偏心半径增加而增大,以在0.3Hz,0.4Hz最为明显,超过此频率范围后增益随半径变化不明显。结论:提取眼震增益的增强率(enhancementratio,ER)可以表达眼震增益随偏心半径增加而增大的增强效应,并作为反映豚鼠前庭耳石器功能的指标,以0.4Hz,半径990mm的正弦旋转模式作为耳石器功能评价的刺激模式较好。To observe the characteristics of vestibular-ocular reflex （VOR） of guinea pigs during eccentric sinusoidal rotation in different frequencies and radius, and compare them with that during axis rotation, obtain the parameters which reflect otolith functions, and provide experimental evidence for the establishment of otolith function test. Methods： Guinea pigs were placed in axis of rotation and in an heading out eccentric position apart from rotation axis of 330 mm, 660 mm and 990 mm respectively, their VOR were recorded and compared under stimulus of sinusoidal rotations in the frequencies of 0.1, 0.2, 0.3, 0.4, 0.5 and 0.6 Hz with the peak velocity of 60°/s in each position. Results： Both frequency and eccentric radius had significant effects on the VOR gain, it increased with the increase of frequencies and radius. The largest increase of the gain occurred at the frequencies of 0.3 and 0.4Hz, and no significant changes were observed above these frequencies. Conclusion： Enhancement ratio （ER） of VOR gain can reflect the ex- tent of its increase with radius, and can be used as an index of otolith function, the stimulus profile ofeccentric rotation at frequency of 0.4Hz and radius of 990mm is recommended as the stimulus profile for the otolith function test.

关 键 词：偏心旋转 耳石器 前庭眼动反射 

分 类 号：Q437[生物学—生理学]