Monitoring of CO2 Tension during High Frequency Jet Ventilation  

作　　者：Xiqing Sun Xingyu Wu 

机构地区：[1]Department of Aerospace Biodynamics, Faculty of Aerospace Medicine, the Fourth Military Medical University, Xi＇an, 710032

出　　处：《Journal of US-China Medical Science》2006年第2期45-49,共5页美中医学（英文版）

基　　金：Supported by the National Natural Science Foundation of China （No. 39760073）.

摘　　要：In general, end-tidal CO2 tension （PetCO2） is well correlated with arterial CO2 tension （PaCO2） during spontaneous and conventional mechanical ventilation in normal lungs. However, it is known that during high frequency jet ventilation （HFJV）, PetCO2 may underestimate PaCO2 because of inadequate washout of the anatomical dead space by a small tidal volume and the relatively slow response time of infrared CO2 analyzers. The purpose of the present study was to investigate the validity of PetCO2 as a reflection of PaCO2 during HFJV in anesthetized dogs with and without histamine-induced lung injury. Twelve mongrel dogs of either sex were randomly divided into two groups： six control dogs and six histamine-induced lung injury dogs. The dogs were anesthetized and then ventilated on HFJV with frequency of 60, 100 or 200 breaths/min at random. After 20 min of each change in ventilator setting, both PetCO2 and PaCO2 were measured simultaneously after decreasing the frequency from 60, 100 or 200 breaths/min to 20 breaths/min for 6-8 breaths. The results showed that with frequency of 60, 100 and 200 breaths/min, there were no significant differences between PaCO2 and PetCO2 in anesthetized dogs. There was a significant correlation （r=0.83, p〈0.01） between PaCO2 and PetCO2. With frequency of 60 and 100 breaths/min, PACO2（5.21 ± 0.86 and 5.78 ± 0.82） was significant higher than PetCO2 （3.58 ± 0.54 and 4.36 ± 0.52） in dogs with histamine-induced lung injury （p〈0.01）. There was a significant correlation （r=0.80, p〈0.01） between PaCO2 and PetCO2. It is suggested that the PetCO2 following a decrease in the jet frequency during HFJV could provide an accurate prediction of PaCO2 in anesthetized dogs with and without histamine-induced lung injury.

关 键 词：high frequency jet ventilation end-tidal CO2 tension HISTAMINE DOGS 

分 类 号：R332[医药卫生—人体生理学]