Two neuropeptides from synganglia of the hard tick, Ixodes sinensis (Acari: Ixodidae)  

作　　者：LI Jianxu LIU Tongguang YANG Hailong XU Xueqing LIU Zhigang LAI Ren 

机构地区：[1]Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China [2]Graduate School of the Chinese Academy of Sciences, Beijing 100009, China [3]Shengyang Orthopaedic Hospital, Shengyang 110044, China [4]College of Biological Sciences, Shenzhen University, Shenzhen518060, China

出　　处：《Chinese Science Bulletin》2006年第22期2743-2747,共5页

基　　金：This work was supported by the National Natural Science Foundation of China(Grant No.30570360);Natural Science Foundation of Yunnan Province(Grant No.2005C0054M);Natural Science Foundation of Jiangsu Province(Grant No.BK2005422)

摘　　要：二 neuropeptides 从 synganglia (中央神经系统) 被孤立努力滴答响， Ixodes sinensis。他们的主要序列被建立 asLeu-Val-Val-Tyr “ Pro-Trp-Thr-Lys 和 Trp-Glu-Lys-Leu-Gly-Ser-Met-Glu-Thr-Leu。由热板生物鉴定， neuropeptide 在由剂量依赖者行为的老鼠的显示的强壮的 antinociceptive 效果， whileneuropeptide b 在孤立的老鼠长带上有一些弛缓的效果。这些 neuropeptides 可能涉及下面调整主人“ s 防御反应。Two neuropeptides were isolated from synganglia （central nervous system） of the hard tick, Ixodes sinensis. Their primary sequences were established as Leu-Val-Val-Tyr-Pro-Trp-Thr-Lys and Trp-Glu-Lys-Leu-Gly-Ser-Met-Glu-Thr-Leu. By hot plate bioassay, neuropeptide a displayed strong antinociceptive effect in mice by a dose-dependent behavior, while neuropeptide b had some relaxant effects on the isolated rat strip. These neuropeptides might be involved in down-regulating the host＇s defensive reaction.

关 键 词：神经肽 弛缓效应 第一序列 生物化学 

分 类 号：Q516[生物学—生物化学]