肺炎支原体感染并支气管哮喘发作患儿血清白细胞介素-15的表达  

Expression of Interleukin-15 in Peripheral Blood of Patients with Mycoplasma Pneumoniae Infection and Bronchitic Asthma Attacking

作　　者：赵瑜[1] 曹兰芳[1] 马敏[1] 余汉卿[1] 

机构地区：[1]上海交通大学医学院附属仁济医院儿科,上海200001

出　　处：《实用儿科临床杂志》2006年第22期1531-1532,共2页Journal of Applied Clinical Pediatrics

基　　金：上海市科技发展基金项目资助(03ZR14120)

摘　　要：目的研究IL-15在肺炎支原体（MP）感染在支气管哮喘发病中的作用。方法收集2003年6月～2005年4月MP感染并支气管哮喘发作患儿、单纯MP下呼吸道感染患儿、非MP下呼吸道感染患儿和正常对照儿童各30例，采用ELISA方法检测各组患儿外周血IL-15水平。结果外周血IL-15水平在MP感染并支气管哮喘发作组[（2．67±0．93）ng／L]明显高于其他各组，外周血IL-15水平在单纯MP下呼吸道感染组[（2．13±0．64）ng／L]和非MP下呼吸道感染组[（2．10±0．83）ng／L]均显著高于正常对照组[（1．02±0．35）ng／L]，单纯MP下呼吸道感染组外周血IL-15水平与非MP下呼吸道感染组相比有所升高。但无显著性差异（P〉0．05）。结论MP感染后机体外周血IL-15水平升高可能参与支气管哮喘的发病过程。Objective To study the role of interleukin （IL） - 15 in mycoplasma pneumoniae （MP） infection and bronchitic asthma attack. Methods There were 30 patients with MP infection and bronchitic asthma attack, 30 lower respiratory infection patients with MP, 30 lower respiratory infection patients without MP and 30 healthy subjects. IL - 15 in peripheral blood was detected by enzyme - linked immunosorbent assay （ELISA）. Results Patients with bronchitic asthma attack and MP infection had a significantly higher level of IL - 15[（2.67±0.93）ng/L] than other groups, IL - 5 in lower respiratory infection patients with or without MP were significantly higher than that in healthy group, and the patients in lower respiratory infection with MP infection [（2.13±0.64）ng/L] was higher than that of patients with lower respiratory infection without MP[（2.10±0.83）ng/L], but the difference had no significance （P 〉 0.05）. Conclusion The increasing of IL - 15 in peripheral blood after MP infection may play a role in bronchitic asthma pathogenesis.

关 键 词：白细胞介素-15 支原体 肺炎 哮喘 儿童 

分 类 号：R725.6[医药卫生—儿科]