微波作用下卤素交换氟化制备氟代苯甲醛及二苯甲酮类化合物  

Synthesis of Fluorinated Benzaldehydes and Diphenyl Ketones via Halogen-exchange Fluorination Promoted by Microwave

作　　者：梁政勇[1] 吕春绪[1] 李斌栋[1] 

机构地区：[1]南京理工大学化工学院,南京210094

出　　处：《化学通报》2006年第11期836-840,共5页Chemistry

基　　金：江苏省科技发展项目(BE2004045)

摘　　要：在微波作用下，采用高效催化剂体系，于中等极性非质子溶剂中经卤素交换氟化高效制备了系列含氟芳香醛（酮）类化合物，产品收率53．3％，92．6％，反应时间较常规加热最多可缩短80％以上。采用中等极性反应溶剂，还叮突出表现出微波对反应促进的“非热效应”，从而大大拓宽了氧化反应溶剂的选择范围。An effective co-catalyst was used in halogen-exchange fluorination of chlorobenzaldehydes and chlorinated diphenyl ketones under the irradiation of microwave. The yield of products was in the range of 53.3% - 92.6% , and the reaction time can be shortened by more that, 80% at most in comparison with that of common heating. In addition, ＂nonthermal effect＂ can be showed obviously when the reaction was carried in medium polar aprotic solvents. So, more kinds of solvents can be used in halogen-exchange fluorination under the irradiation of microwave.

关 键 词：微波化学 卤素交换氟化 氟代苯甲醛 氟代二苯甲酮 非热效应 

分 类 号：O625.4[理学—有机化学]