新型纤维素衍生物手性固定相的制备及其对几种对映异构体的高效液相色谱分离  

Preparation of Cellulose Derivative as Stationary Phase of High Performance Liquid Chromatography and Its Application to the Separation of Enantiomers

作　　者：孙艳伟[1] 梁晓梅[1] 周志强[1] 吴景平[1] 王道全[1] 

机构地区：[1]中国农业大学应用化学系,北京100094

出　　处：《分析化学》2006年第U09期257-259,共3页Chinese Journal of Analytical Chemistry

摘　　要：合成了一种经环十二烷修饰的纤维素酯,将其涂敷于小粒径的氨丙基化硅胶(APS)上,制备出高效液相色谱手性固定相,以正己烷、异丙醇为流动相拆分了2-对氯苯基丙腈、1-对氟苯基乙醇、1-对叔丁基苯氧基-2-丙醇、2-对氯苯基辛腈及三唑醇等5种外消旋对映体,并考察了流动相中异丙醇含量对分离效果的影响。Cellulose was modified by cyclododecyl and coated onto an aminopropylated mesopore spherical silica gel. The final product was used as the chiral stationary phase of high performance liquid chromatography for the enantioseparation of five enantiomers in the hexane and isopropanol, The compound were CH3CH（p-ClC6H4）CN, CH3CH（p-FC6H4）OH, CH3CHOHCH2[p-C（CH3）3CC6H4], CH3（CH2）5CH（p-ClC6H4）CN and triadimenol.. The effect of isopropanol concentration in the mobile phase on separation was investigated.

关 键 词：纤维素衍生物 手性固定相 高效液相色谱 

分 类 号：O657.72[理学—分析化学]