毛细管微乳液电动色谱和胶束电动色谱分离冰毒及其麻黄碱杂质的比较  

Comparison of the Performance of Microemulsion Electrokinetic Chromatography and 1-Butanol Modified Micellar Electrokinetic Chromatography on the Separations of Amphetamine and It′s Ephedra Alkaloid Impurities

作　　者：温涛[1] 赵霞[2] 罗国安[1] 王义明[1] 王俭 朱军[4] 于忠山[4] 

机构地区：[1]清华大学化学系,北京100084 [2]北京市公安局法医检验检测中心,北京100085 [3]公安部科技局,北京100741 [4]公安部物证鉴定中心,北京100038

出　　处：《分析化学》2006年第11期1529-1534,共6页Chinese Journal of Analytical Chemistry

基　　金：国家科技部十五攻关(No.2001DA801B04);国家863(No.2002AA2Z2004)基金资助项目

摘　　要：通过毛细管微乳液电动色谱10 m in内同时分离了安非他明、甲基安非他明、4,5-亚甲基二氧基安非他明(MDA)和3-甲氧基-4,5-亚甲基二氧基安非他明(MDMA)4种苯丙胺类毒品及其麻黄碱、伪麻黄碱、甲基麻黄碱、甲基伪麻黄碱、去甲麻黄碱等麻黄生物碱杂质。比较了毛细管微乳液电动色谱和丁醇改进的胶束电动色谱模式对分离的影响,发现正丁醇是影响分离的最主要因素。本方法具有很好的重复性和稳定性,可实现对冰毒及其麻黄生物碱杂质的快速分析和鉴定,相对保留时间和相对峰面积的RSD分别小于1.3%和5.0%,可用于冰毒的实际来源推断。Simultaneous separation of 9 speci was conducted within 10 minutes by capillary es of amphetamines and their microemulsion electrokinetic separation performance of microemulsion electrokinetic ch micellar electrokinetic chromatography with 1-butanol as basic ephedra alkaloid impurities chromatography. Meanwhile, the romatography was compared with the separation by modifier, and the influences of pH and 1-butanol cosurfactant on the separations were investigated, and 1-butanol was found to be a principal factor to improve separation efficiency in the two separation modes. The developed microemulsion electrokinetic chromatographic method for separation of amphetamine is stable, and the RSDs for relative migration time and relative peak area are less than 1.3% and 5.0% respectively, so it can be applied in the analysis and determination of practical amphetamine samples.

关 键 词：冰毒 麻黄碱 毛细管微乳液电动色谱 毛细管胶束电动色谱 分离 

分 类 号：D919[医药卫生—法医学]