中国人群HLA-DRB1基因多态性与慢性乙型肝炎关系的Meta分析  

Meta-analysis on the relationship between HLA-DRB1 gene polymorphism and chronic hepatitis B in Chinese population

作　　者：骆峻[1] 金安娜[2] 吴旭东[2] 喻荣彬[1] 

机构地区：[1]南京医科大学公共卫生学院流行病与卫生统计学系,江苏省南京市210029 [2]江苏职工医科大学医学微生物学教研室,江苏省南京市210029

出　　处：《世界华人消化杂志》2006年第31期3050-3054,共5页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助课题;No.30200232~~

摘　　要：目的:用Meta分析的方法综合评价中国人群HLA-DRB1基因多态性与慢性乙型肝炎的关系.方法:检索中国生物医学文献数据库、维普数据库和Medline数据库,依据选择标准收集所有相关的病例对照研究,应用RevMan4.2软件对符合条件的研究结果进行Meta分析.结果:符合纳入标准的共8篇文献,包含慢性乙型肝炎组501例和正常对照组855例.经综合分析:HLA-DRB1*03和HLA-DRB1*08可能为中国人群慢性乙型肝炎的易感性基因型(OR=2.44,95%CI:1.65-3.61,P<0.00001;OR=1.57,95%CI:1.08-2.28,P=0.02);HLA-DRB1*13和HLA-DRB1*15可能是我国人群慢性乙型肝炎的保护性基因型(OR=0.40,95%CI:0.21-0.79,P=0.008;OR=0.64,95%CI:0.46-0.90,P=0.01).结论:中国人群慢性乙型肝炎的发生与HLADRB1基因的多态性有关,与其他国家人群既有相同点,也有其自身特点.AIM： To assess the associations of HLA-DRB1 gene polymorphism with chronic hepatitis B in Chinese population. METHODS： A comprehensive search for articles from 1998 to 2006 was conducted from Chinese Biomedical Literature Database on disc （CBMdisc）, VIP and Medline databases. A total of 8 epidemiological case-control studies on the relationship between gene polymorphism of HLA- DRB1 and chronic hepatitis B were performed and the results were analyzed using RevMan 4.2 software. RESULTS： A total of 501 patients with chronic hepatitis B and 855 uninfected healthy controlswere included from the 8 studies. HLA-DRBI＊03 and HLA-DRBI＊08 alleles were the risk factors of CHB, the values of pooled odds ratio were 2.44 （95%CI： 1.65-3.61, P 〈 0.00001） and 1.57 （95%CI： 1.08-2.28, P=0.02）, respectively. HLA-DRB1＊13 and HLA-DRB1＊15 alleles were the protection factors against CHB, and the values of pooled odds ratio were 0.40 （95%CI： 0.21-0.79, P=0.008） and 0.64 （95%CI： 0.46-0.90, P = 0.01）, respectively. CONCLUSION： The occurrence of CHB is associated with the gene polymorphism of HLA- DRB1 in Chinese population.

关 键 词：慢性乙型肝炎 人类白细胞抗原Ⅱ HLA-DRB1 基因多态性 META分析 

分 类 号：R512.62[医药卫生—内科学]