阿奇霉素对慢性鼻窦炎鼻息肉患者术腔黏膜上皮化的影响  

Effect of Azithromycin on nasal mucosa of chronic sinusitis after endoscopic sinus surgery

作　　者：白永[1] 李娜[1] 张念凯[1] 

机构地区：[1]青岛大学医学院附属医院耳鼻咽喉-头颈外科,山东青岛266003

出　　处：《山东大学耳鼻喉眼学报》2006年第5期413-415,共3页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的：观察阿奇霉素对慢性鼻窦炎鼻息肉患者术后术腔黏膜上皮化的影响。方法：随访59例行鼻内镜手术的慢性鼻窦炎、鼻息肉患者，患者术后均用布地奈德喷鼻，1月后头孢菌素组37例加用头孢丙烯500mg，口服，每日1次，共3周；阿奇霉素组22例加用阿奇霉素500mg，口服，每日1次，共3周；观察2组术腔黏膜上皮化的情况和时间。结果：随访6个月，头孢菌素组28例上皮化，9例在随访期间未上皮化；阿奇霉素组22例均上皮化，两组比较差异有统计学意义（7。=4．573，P=0．033）。头孢菌素组22～126d黏膜上皮化，平均（51．143±27．655）d，阿奇霉素组11～83d上皮化，平均（33．046±18．874）d，两组差异有统计学意义（t=2．624，P=0．006）。结论：阿奇霉素治疗慢性鼻窦炎鼻息肉术后术腔黏膜慢性炎症、促进术腔黏膜上皮化有良好的疗效，可作为患者术后治疗的一种选择。Objective： To observe the effect of Azithromycin on the epithelialization of nasal mucosal of chronic sinusitis after endoscopic sinus surgery. Methods： From December 2004 to December 2005, 59 patients with chronic sinusitis and/or nasal polyp were treated with endoscopic surgery. One month after the operation, they were divided into two groups, and 37 patients were treated with cephamycin as a control group and 22 with Azithromycin as a experimental group. The course and the number of epithelialization were counted. Results： Within 6 months, epithelialization happened in 22-126 days（ average 51. 1423 ± 27.655 days） in control group, and in 11-88 days（ average 33.046 ± 18. 874 days） in experimental group, and the difference was statistically significant（ t = 2.624, P = 0.006）. Epithelialization happened in 28 cases in the control group and 22 cases in experimental group, and the difference was also statistically significant （Z2 = 4.573, P = 0.033）. Conclusion： Azithromycin is effective in accelerating the epithelialization of nasal mucosa after endoscopic sinus surgery.

关 键 词：鼻窦炎 慢性 外科手术 鼻黏膜 阿奇霉素 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]