非小细胞肺癌血管内皮生长因子-C和Survivin蛋白的表达及其对患者预后的影响  

Expression of Vascular Endothelial Growth Factor-C and Survivin Protein in Non-small Cell Lung Carcinoma and Its Effect on the Patients' Prognosis

作　　者：张惠忠[1] 魏益平[1] 华平[1] 李海刚[2] 刘金耿[1] 吴澄[1] 曹永科[1] 

机构地区：[1]中山大学附属第二医院心胸外科,广东广州510120 [2]中山大学附属第二医院病理科,广东广州510120

出　　处：《中山大学学报（医学科学版）》2006年第6期681-685,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广州市科委科技攻关引导资助项目(02Z3-E0016)

摘　　要：【目的】研究血管内皮生长因子-C(VEGF-C)和survivin蛋白在非小细胞肺癌(NSCLC)组织中的表达及其与肺癌生物学行为的关系。【方法】应用免疫组化方法检测77例NSCLC组织中VEGF-C和survivin蛋白的表达,分析其与肿瘤大小、肿瘤淋巴管密度(LVD)、组织类型、分化程度、淋巴结转移、临床复发情况和患者术后生存时间的关系。【结果】77例NSCLC组织中,有45例VEGF-C蛋白表达呈阳性(58.4%);有41例survivin蛋白表达呈阳性(53.2%)。VEGF-C蛋白的阳性表达组肿瘤大小和LVD均高于阴性组(P<0.05),VEGF-C蛋白的表达与患者术后生存时间呈负相关(P<0.05)。Survivin蛋白的阳性表达组的LVD高于阴性组(P<0.05),survivin蛋白的表达与NSCLC淋巴结转移(r=0.324,P<0.05)和临床复发呈正相关(r=0.233,P<0.05),与患者术后生存时间呈负相关(P<0.05)。VEGF-C和survivin蛋白在NSCLC组织中的表达之间呈正相关性(r=0.266,P<0.05)。【结论】VEGF-C和survivin蛋白的表达与非小细胞肺癌的生物学行为具有相关性,它们的高表达提示非小细胞肺癌患者预后不良。[Objective] To investigate the expression of vascular endothelial growth factor-C （VEGF-C） and survivin proteins, and its relationship with biological behaviors of non-small cell lung carcinoma （NSCLC）. [Methods] Immunohistochemical staining was used to detect the expression of VEGF-C and survivin proteins in 77 cases of NSCLC. The relationship was analyzed between the expression of VEGF-C, survivin and tumor size, lymphatic vessel density （LVD）, histological type, differentiation, lymphoid nodular metastasis, clinical recurrence and survival time of the patients. [Results ] Out of 77 cases of NSCLC, 45 cases （58.4%） showed positive expression of VEGF-C protein and 41 cases （53.2%） showed positive expression of survivin protein, respectively. Both tumor size and LVD were larger in the positive expression group of VEGF-C than the negative one （P 〈 0.05）. The expression of VEGF-C protein was associated negatively with the survival time （P 〈 0.05）. The LVD was larger in positive expression group of survivin than negative one （P 〈 0.05）.The expression of survivin was associated with lymphoid nodular metastasis （r=0.324,P〈 0.05） and clinical recurrence positively （r=0.233, P〈 0.05） and was associated the survival time negatively （P 〈 0.05）. The expression of VEGF-C was associated with the expression survivin proteins positively （r=0.266,P〈 0.05）. [Conclusion ] The expressions of VEGF-C and survivin proteins are closely associated with the biological behaviors of NSCLC, those high expressions suggest poor prognosis.

关 键 词：肺肿瘤 免疫组织化学 VEGF—C SURVIVIN 预后 

分 类 号：R655[医药卫生—外科学] R730.3[医药卫生—临床医学]