甲醇中毒导致脑部损害的影像学表现  

Imaging study of brain damage from methanol intoxication of wine

作　　者：于成福[1] 刘移民[1] 杨艺[1] 史晶[1] 吴一行[1] 张维森[1] 毛晓芬[1] 骆晶[1] 

机构地区：[1]广州市白云区人民医院放射科,510500

出　　处：《中华放射学杂志》2006年第11期1133-1135,共3页Chinese Journal of Radiology

摘　　要：目的探讨甲醇中毒导致脑部损害的CT、MRI特点及与其发病相关因素的关系。方法39例饮假酒致甲醇中毒的患者,发病的潜伏期为0～4d。发病后1～6d行血液学检查、头颅CT平扫,其中4例行头颅MR平扫。结果双侧壳核低密度改变6例,其中合并双侧皮质下白质区低密度改变2例;单侧内囊低密度改变4例;皮质下白质区低密度改变1例。CT阳性与饮假酒量(Z=-2.244,P<0.05)、临床分期呈正相关(χ2=4.232,P<0.05);与血液中甲醇浓度(Z=-1.430,P>0.05)、潜伏期(χ2=0.001,P>0.05)无明显相关性。结论MRI较CT更能早期发现脑部损害。病变的特点以双侧壳核发病为主,合并皮质下白质区的损害者往往提示预后不佳。Objective To investigate the imaging of CT and MRI in brain damage caused by methanol intoxication from false wine, and to study the relations between imaging manifestation and different degrees of the methanol intoxication. Method Thirty nine cases with methanol intoxication from false wine were retrospectively reported, The latent period of these patients was 0-4 days, and the average latent period of these patients was 0. 5 days, All cases were performed by serology examination, brain CT scan, and four cases performed by MRI scan after average 2. 5 days （ range, 1-6 days ） the onset of methanol intoxication. Results Six cases showed hyperintense signals in bilateral putamen, two cases also showed hyperintense signals in hiolateral subcortex white sustance regions.Four cases showed hyperintense signals in unilateral internal capsule. One case showed hyperintense changess in subcortex white substance regions. Our study showed the positive correlation between CT features and the amount of methanol and stage of clinic manifestation（X^2=4.232,P〈0.05）,It was not significantly related to concentration of methanol, latent period and age of the patients （X^2=0.001,P〉0.05）.Conclusions MRI was better than CT in finding early brain damage eaused by methanol intoxication from false wine. The characteristic finding changes of the patients was showed mainly in in bilateral putamen, Prognosis for the patients combined with subcortex white substance lesion wasn＇t hopeful.

关 键 词：体层摄影术 X线计算机 磁共振成像 甲醇 中毒 

分 类 号：R445[医药卫生—影像医学与核医学]