t-PA对深静脉血栓合并肺血栓栓塞症患者的鉴别意义  

Significance of Tissue Type Plasminogen Activator in Diagnosis of Pulmonary Thromboembolism with Deep Venous Thrombosis

作　　者：尚跃丰[1] 陈永利[1] 张敬霞[2] 袁志明[1] 王佩显[1] 

机构地区：[1]天津医科大学总医院,300052 [2]天津市胸科医院

出　　处：《天津医药》2006年第11期756-758,共3页Tianjin Medical Journal

基　　金：天津市自然科学基金重点资助项目(项目编号:013609011)

摘　　要：目的:观察血浆组织型纤溶酶原激活物(tissuetypeplasminogenactivator,t-PA)在深静脉血栓形成(deepvenousthrombosis,DVT)患者中,对于鉴别合并肺血栓栓塞症(pulmonarythromboembolism,PTE)的意义。方法:分别测定DVT患者(66例)和DVT合并PTE患者(44例)血浆中的t-PA含量。结果:DVT合并PTE组的血浆t-PA含量明显高于DVT组(中位数分别为33.88μg/L和13.80μg/L,P<0.01)。ROC曲线确定t-PA的诊断截断值为7.42μg/L,其敏感性、特异性、阳性预测值、阴性预测值和约登指数分别为90.9%、39.5%、46.51%、88.24%、0.514。结论:DVT患者血浆t-PA含量对于鉴别是否合并PTE有一定参考价值。Objective： To observe the value of tissue type plasminogen activator （t-PA） in diagnosing pulmonary thromboembolism （PTE） with deep venous thrombosis （DVT）. Methods： The level of plasma t-PA was measured in 66 DVT patients and 44 DVT＋PTE patients. Results： The level of plasma t-PA in patients with DVT＋PTE was significantly higher than that in patients with DVT （median value：33.88 μg/L versus 13.80 μg/L, P〈0.01）. The receiver operator characteristic curve （ROC） determined the cutoff point of t-PA that using to differentiating DVT＋PTE from DVT patients. The sensitivity, specificity, positive predictive value, negative predictive value and Younden＇s index of this cutoff point were 90.9%, 39.5%, 46.51%, 88.24% and 0.514, respectively. Conclusion; The level of plasma t-PA in DVT patients with PTE was higher than that in DVT patients which could be of some significance in detection of PTE in DVT patients.

关 键 词：组织型纤溶酶原激活物 静脉血栓形成 肺栓塞 

分 类 号：R543.6[医药卫生—心血管疾病]