Synthesis and Characterization of Novel Thiosemicarbazones Bearing Sugar Moieties  

作　　者：YANG Bo ZHANG Shu-sheng LI Hui-xiang 

机构地区：[1]College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China

出　　处：《Chemical Research in Chinese Universities》2006年第6期738-741,共4页高等学校化学研究（英文版）

基　　金：Supported by the Program for New Century Excellent Talents in University(No. NCET-04-04649);the National Natural Sci-ence Foundation of China(No 20475030);the Start-up Fund for Doctoral Scientific Research of Qingdao University of Science andTechnology.

摘　　要：Six novel thiosemicarbazones containing sugar and thiosemicarbazide moieties were synthesized by a five-step procedure using D-galactose and D-xylose as the starting materials and the corresponding glycosyl isothiocyanates as the intermediates. The target compounds were characterized by IR, ^1H NMR, and elemental analysis. The coupliug constants between H1 and H2 in the sugar rings, all fail within the range of J = 9. 2-10.0 Hz, confirming the β-configuration of the compounds.Six novel thiosemicarbazones containing sugar and thiosemicarbazide moieties were synthesized by a five-step procedure using %D%-galactose and %D%-xylose as the starting materials and the corresponding glycosyl isothiocyanates as the intermediates. The target compounds were characterized by IR, {}1H NMR, and elemental analysis. The coupling constants between H1 and H2 in the sugar rings, all fall within the range of J=9.210.0 Hz, confirming the β-configuration of the compounds.

关 键 词：THIOSEMICARBAZONE SUGAR SYNTHESIS Characterization 

分 类 号：Q517[生物学—生物化学]