一种灰树花菌丝体多糖GF4F1的结构特征及其抗肿瘤活性  

Structural Characterization and Antitumor Activity of Polysaccharide GF4F1 from Grifola frondosa Mycelium

作　　者：于广利[1] 李春林[1] 赵峡[1] 杨晓华[1] 宋乐天[1] 高昊东[1] 

机构地区：[1]中国海洋大学海洋药物与食品研究所,山东青岛266003

出　　处：《中国海洋大学学报（自然科学版）》2006年第6期915-918,974,共5页Periodical of Ocean University of China

基　　金：国家自然科学基金项目(30370345);青岛市科技局项目(05-2-NS-27)资助

摘　　要：以灰树花发酵菌丝体为原料,经过提取分离纯化得到1种水溶性多糖GF4F1,经高碘酸氧化、Smith降解、甲基化、红外光谱(IR)以及核磁共振波谱(NMR)等分析表明,该多糖是1种β-1,3/1,6-葡聚糖,且小鼠体内实验结果表明其具有良好的抗肿瘤活性。在1 mg/kg时,对小鼠抑制率为67.3%。A polysaccharide （GF4F1）was extracted and purified from fermented Grifola frondosa mycelium. The structural characterization of GF4F1 was analyzed by NaIO4 oxidation, Smith degradation, methylation, IR and NMR techniques. The results showed that GF4F1 was β-1, 3/1, 6- D-Glucan, and showed good anti-tumor activity in mice. The inhibition rate to S180 in mice was 67.3 % at 1 mg/kg.

关 键 词：灰树花菌丝体 β-1 3/1 6葡聚糖 结构 抗肿瘤活性 

分 类 号：R282.71[医药卫生—中药学]