BMPR-IB基因作为绵羊多胎性能候选基因的研究  

Study on Bone Morphogenetic Protein Receptor IB as a Candidate Gene for Prolificacy in Sheep

作　　者：朱二勇[1] 史洪才[1] 武坚[1] 刘明军[1] 简子健[2] 白杰[3] 徐新明[2] 

机构地区：[1]新疆畜牧科学院农业部家畜繁育生物技术重点开放实验室,乌鲁木齐830000 [2]新疆农业大学动物医学学院,乌鲁木齐830052 [3]石河子大学,新疆石河子832000

出　　处：《西北农业学报》2006年第6期20-23,共4页Acta Agriculturae Boreali-occidentalis Sinica

基　　金：新疆维吾尔自治区自然科学基金(No:200421103)

摘　　要：利用BMPR-IB基因作为湖羊、小尾寒羊及中国美利奴(新疆型)多胎类型多胎性能候选基因,采用PCR-RFLP方法和聚丙烯酰胺凝胶电泳分析该基因在湖羊、小尾寒羊和中国美利奴(新疆型)多胎类型中的多态性,并与其产羔数进行相关性分析,结果3种羊在BMPR-IB基因编码序列746碱基处均检出与BooroolaMerino相同的A→G突变,可分为3种基因型(BB型、B+型和++型)。湖羊中几乎全部为BB基因型;小尾寒羊中以BB和B+基因型为主;中国美利奴(新疆型)多胎类型中以B+基因型为主;BMPR-IB基因与产羔数显著相关,是上述3种羊的多胎主效基因。BMPR-IB gene as a fecundity candidate gene was studied in Small Tail Han sheep, Hu sheep and Chinese Merino（Xinjiang type）fecundity line by PCR-RFLP. The results showed that there was a same mutation （A→G） of BMPR-IB gene in three breeds sheep as that in Booroola merino ewes o Three genotypes（BB.B＋ .＋ ＋）were found and almost all were the genotype BB in Hu sheep ,and the BB and B＋ were inferior in Small Tail Han sheep, B＋ was the major genotype in Chinese Merino （Xingjian type）fecundity line,The BMPR IB gene is significantly related with the little size of sheep.

关 键 词：骨形态发生蛋白受体IB基因(BMPR—IB) 多胎性 绵羊 

分 类 号：S826[农业科学—畜牧学]