血小板活化因子诱发豚鼠气道高反应性及阿魏酸钠对其的影响  

PAF induced airway hyperresponsiveness and effects of sodium ferulate in guinea pigs

作　　者：孙云[1,2] 林安平[1,2] 张洪泉[1,2] 卞如濂[1,2] 

机构地区：[1]扬州大学医学院药理教研室 [2]浙江医科大学平喘药研究室

出　　处：《中国药理学通报》1996年第6期518-520,共3页Chinese Pharmacological Bulletin

基　　金：江苏省自然科学基金

摘　　要：正常豚鼠吸入血小板活化因子（ＰＡＦ）２４ｈ后气道对组胺引起的收缩反应性明显增高，支气管肺泡灌洗液中的嗜酸性白细胞计数明显增多。用兔抗豚鼠血小板血清选择性耗竭血小板，向气道内注入肝素，或用阿魏酸钠２５，５０和１００ｍｇ·ｋｇ－１，ｉｖ均可不同程度抑制ＰＡＦ诱发的气道高反应性和嗜酸性白细胞向肺内募集。Aerosol administration of platelet activating factor(PAF) to normal guinea pigs induced an enhanced airway responsiveness to inhaled histamine, 24 h after exposure. The number of eosinophils in the lungs as assessed by bronchoalveolar lavage increased 1Anti asthmatic Agents Research Institute, Zhejiang Medical University, Hangzhou 310006 significantly. The airway hyperresponsiveness could be inhibited by selective platelet depletion with a rabbit anti guinea pig platelet serum; instilation of heparin to airway and sodium ferulate 25, 50 and 100 mg·kg -1 administration intravenously.

关 键 词：阿魏酸钠 血小板活化因子 气道高反应性 

分 类 号：R974.3[医药卫生—药品] R965.1[医药卫生—药学]