硫酸黄连素对免疫系统的影响  

Effects of berberine sulphate on immune system

作　　者：耿东升[1,2] 刘发[1,2] 刘学彬[1,2] 杨永新[1,2] 

机构地区：[1]新疆医学院药理教研室 [2]新疆军区药材库

出　　处：《中国药理学通报》1996年第6期536-539,共4页Chinese Pharmacological Bulletin

摘　　要：用硫酸黄连素（ｂｅｒｂｅｒｉｎｅｓｕｌｐｈａｔｅ，ＢＳ）对小鼠的整体及离体试验，探索其对免疫系统的影响。结果表明：ＢＳ１０－４，１０－５ｍｏｌ·Ｌ－１可增强腹腔巨噬细胞（ＰＭΦ）和人全血白细胞吞噬白葡萄球菌的功能；促进小鼠ＰＭΦ产生ＩＬ－１；抑制脾细胞产生ＩＬ－２和抑制Ｔ和Ｂ淋巴细胞转化；２５，５０ｍｇ·ｋｇ－１加速小鼠网状内皮系统对炭粒的廓清速率；抑制小鼠血清溶血素的产生和足跖的ＤＴＨ反应。提示ＢＳ可增强小鼠非特异免疫反应，抑制细胞和体液免疫功能。In previous studies, it found that berberine had the effects of antibacteria, anti inflamation and restraining the growth of tumor cells. These should have been closely connected with immunity effects. Therefore, we had studied the effects of berberine sulphate (BS) on immune system of mice in vitro and vivo . The results showed that BS with 10 -4 and 10 -5 mol. L -1 increased phagocytosing function of peritoneal macrophages (PMΦ) in mice and peripheral leukocytes in human, the production of IL 1 by PMΦ in mice, inhibited the production of IL 2 produced by spleen cells, the lymphocyte transformatiom of both T and B. With 25,50 mg·kg -1 , BS accelerated the clearance rate of charcoal particles, decreased the development of serum hemolysin concentration 50% and the delayed type hypersensitivity reaction. It was suggested that BS increase non specific and decrease specific immunity in mice.

关 键 词：硫酸黄连素 吞噬作用 淋巴细胞转化 白细胞介素 

分 类 号：R285.5[医药卫生—中药学] R967[医药卫生—中医学]