糖皮质激素性骨质疏松症的实验研究  

Experimental study of glucocorticoid induced rabbit osteoporosis

作　　者：陈能[1] 田鸾英[1] 刘仲熊[1] 张丙宏[1] 张水堂[1] 

机构地区：[1]湖北医科大学附一儿科

出　　处：《中国药理学通报》1996年第6期540-542,共3页Chinese Pharmacological Bulletin

摘　　要：为探讨糖皮质激素不同给药方式，累积量及辅钙剂、维生素Ｄ（ＶｉｔＤ）对骨组织影响，３０只大白兔被分为激素不同治疗组，测定血清钙、磷、碱性磷酸酶、氨基端甲状旁腺素（ＰＴＨ）及骨密度。结果显示辅钙剂、ＶｉｔＤ组骨密度及ＰＴＨ与对照组无差别（Ｐ＞０．０５），隔日及大剂量组骨密度下降、ＰＴＨ升高（Ｐ＜０．０５），且大剂量组较隔日组明显（Ｐ＜０．０５）。说明糖皮质激素性骨质疏松症与激素的剂量有关，发病机制涉及继发性甲旁亢，隔日疗法不能阻止骨质丢失，补充钙剂、ＶｉｔＤ有预防治疗作用。To study the effect of variant administration and cumulative dose of glucocorticoid on the skeleton, thirty male rabbits were divided into 5 groups, serum calcium, phosphirus, alkaline phosphatase and N terminalfragment of parathyroid hormone (PTH) and bone mineral content (BMC) were determined, The results showed no significant differ ences were observed between supplerment calcium group and control group at the level of BMC and PTH (P>0 05) , but there were significantly decreased BMC and elevated PTH in other groups (P<0 01) , especially in the high dose group. The results indicated that glucocorticoid induced osteoporosis is associated with the steroid dose, and the pathogenesis is concerned with the development of secondary hyperparathyroidism. Alternate day therapy cant prevent bone loss. Supplementation of calcium and vitamin D is an effective method for the prevention and treatment.

关 键 词：糖皮质激素 骨质疏松症 骨密度 骨状旁腺素 

分 类 号：R681.02[医药卫生—骨科学] R977.1[医药卫生—外科学]