肝病患者丙型肝炎病毒感染及C基因分型  

PREVALENCE OF HEPATITIS C VIRUS INFECTOIN AND ITS GENOTYPE IN PATIENTS WITH LIVER DISEASES

作　　者：姚登福 孟宪镛 葛政举 黄介飞 倪润洲 张弘 魏群 肖明兵 清水一郎[1] 伊东进 

机构地区：[1]南通附属医院内科,日本国德岛大学

出　　处：《南通医学院学报》1996年第4期490-492,共3页ACTA Academiae Medicinae Nantong

摘　　要：以第２代抗体法分析急、慢性肝病患者中丙型肝炎病毒（ＨＣＶ）感染，并对ＨＣＶ阳性者以型别特异的逆转录聚合酶链反应进行Ｃ基因分型，在６４４例肝病患者中，第２代抗体阳性率为肝癌７．３％、急性肝炎３．４％、慢性肝炎６．６％、肝硬化６．６％；非肝病患者１０６例中，阳性串为３．８％。慢性肝炎ＨＢＶ感染达８９．５％。４１例ＨＣＶ阳性者的Ｃ基因公型显示：Ⅱ型占８５．４％、Ⅲ型７．３％、Ⅱ／Ⅲ混合型７．３％，未见其他型感染。本文资料提示，南通地区ＨＣＶ感染以Ⅱ型为主，其感染卒远较ＨＢＶ感染为低。The incidence of hepatitis C lirus(HCV)infection in patients with liver diseases was investigated by a second generation antibody assay and HCV present in 41 anti-HCV positive patients was characterized by genotype-specific RT-PCRs. Of 644 patients with liver diseases,the incidence of anti-HCV was 7.3%in hepatocellular carcinoma,3.4%in acute hepatitis,6.6%in chronic hepatitis,6,6%in liver cirrhosis and 3.8%in patients with other diseases,respectively. The higher incidence(89.5%)of HBV infection was found in patients with chronic hepatitis.Among the 41 anti-HCV positive patients,HCV genotype Ⅱ was dominant(85.4%),follocoed by genotype Ⅲ(7.3%)and mixed Ⅱ/Ⅲ(7.3%),no genotype Ⅰ or Ⅳ was found.The ptesent data suggest that HCV genotype Ⅱ appears to be predominant in Nantong and HCV infection shows lower prevalence than HBV in patients with liver diseases.

关 键 词：丙型肝炎病毒 抗体 基因 分型 肝病 

分 类 号：R512.630.3[医药卫生—内科学] R373.21[医药卫生—临床医学]