解脲脲原体与新生儿感染  

Ureaplasmaurealyticumandneonatalinfection

作　　者：孙红妹[1,2] 郭章溉[1,2] 吴连方[1,2] 

机构地区：[1]首都儿科研究所 [2]北京妇产医院

出　　处：《中华医学检验杂志》1996年第6期364-365,共2页

基　　金：国家自然科学基金

摘　　要：目的确定解脲脲原体（Ｕｕ）与新生儿肺炎等感染的关系。方法用间接血凝试验（ＩＨＡ）检测妊娠晚期孕妇血清Ｕｕ抗体，并对胎盘做Ｕｕ分离培养，用酶联免疫吸附试验（ＥＬＩＳＡ）检测部分胎儿脐血清Ｕｕ－ＩｇＭ抗体。并对孕妇血清Ｕｕ抗体阳性组和阴性组新生儿感染情况进行比较。结果１６０名孕妇血清中，８１例Ｕｕ抗体阳性，从其中１３例的胎盘中分离培养出Ｕｕ。用ＥＬＩＳＡ法检测５例胎盘Ｕｕ阳性的新生儿脐血Ｕｕ－ＩｇＭ，３例阳性。孕妇血清抗体阳性组的新生儿肺炎１６例，发热者１０例，两者总发病率为５４．５％，较阴性组高（３７．９％，Ｕ检验Ｐ＜０．０５）。结论Ｕｕ是引起新生儿感染。ObjectiveToascertaintherelationbetweenneonatalinfectionandUreaplasmaure-alyticum(Uu),westudied160normalhealthypregnantwomenandtheirneonates.MethodsSerumspecimensfrompregnantwomenwerecolectedbeforedelivery,andsenttoourlabforserologicaltests.Indirecthemagglutinatingantibody(HA)wasdeterminedbyusingsensitivesheepredcelofUuantigen.Uu-IgMincordbloodfromsomeneonateswastestedbyELISA.ResultsOfthe160pregnantwomen,81hadelevatedlevelsofUuantibody.Therewasahighermorbility(54.5%)a-mongneonateswithneonatalinfectionwhosemothershadelevatedlevelsofureaplasmaantibody.16neonateshadpneumoniaand10neonateshadfeverwithoutreason.Inthecontrolswithoutelevatedlevelstoureaplasmaantibody,themobilityamongtheirneonateswas37.9%.Therewasasignifi-cantdiference(P<0.05)betweenthetwogroup.ConclusionThesedataindicatethatureaplasmaurealyticummaybeanimportantpathogeneinneonatalinfection,especialyinneonatalpneumonia.

关 键 词：解脲脲原体 新生儿 感染 

分 类 号：R722.130.3[医药卫生—儿科] R374.3[医药卫生—临床医学]