抗瘤I号对小鼠脾淋巴细胞增殖及外周血白细胞数的影响  

Effects of AT-I on Murine Lymphocyte Proliferation of Spleen and Numbers of PBWBC

作　　者：雷秀玲[1] 楚延[1] 

机构地区：[1]昆明医学院药理学教研室,华西医科大学基础药理学教研室

出　　处：《昆明医学院学报》1996年第2期12-14,共3页Journal of Kunming Medical College

摘　　要：抗瘤Ｉ号（ＡＴ－Ｉ）是临床抗肿瘤及辅助肿瘤治疗有效的中药胶囊剂，具有肯定的抑瘤效应及调节小鼠脾细胞ＩＬ－２，ＩＬ－６产生和ＮＫ细胞活性的作用，为了探讨其辅助肿瘤治疗的机理，观察了ＡＴ－Ｉ对正常、免疫受抑制和荷瘤小鼠脾淋巴细胞增殖和外周血ＷＢＣ数的影响，结果提示：ＡＴ－Ｉ低剂量能促进脾细胞增殖，大剂量反呈现抑制效应；同时，ＡＴ－Ｉ还能纠正环磷酰胺减少外周血ＷＢＣ数的不良反应．Antitumor-I(AT-I)is a traditional chinese medicine,which is known to becombined with chemotherapeutic agents on antitumor effects.It is demonstrated that AT-I can inhibit tumor growth and modulate IL-2 ,IL-6 and NK cell activities by splenocytes in vi-vo. In this study,the results suggest that AT-I in lower dose can enhance splenocytes prolif-eration while in higher dose can inhibit it.AT-I can antagonize on adverse reaction of reduc-tion PBWBC when it is combinated with cyclophosphamide(CPA).

关 键 词：抗瘤I号 脾 淋巴细胞 白细胞 中药品 胶囊 

分 类 号：R286[医药卫生—中药学] R285.5[医药卫生—中医学]