丹参注射液对失代偿期肝硬化患者凝血功能的影响  

Effects of salvia miltiorrhiza injection on coagulation function of decompensated liver cirrhosis

作　　者：胡国勇[1] 胡娟[2] 严志刚[1] 丁岩冰[1] 吴健[1] 肖炜明[1] 杨建国[1] 

机构地区：[1]扬州市第一人民医院消化内科,江苏省扬州市225001 [2]扬州市第一人民医院检验科,江苏省扬州市225001

出　　处：《世界华人消化杂志》2006年第32期3147-3150,共4页World Chinese Journal of Digestology

摘　　要：目的:评价丹参注射液对失代偿期肝硬化患者凝血功能的影响.方法:失代偿期肝硬化患者40例随机平均分为丹参治疗组和对照组,前者在综合治疗的基础上加用丹参注射液治疗,治疗前及治疗后2wk测定凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)等凝血功能指标,并观察两组治疗期间临床出血情况.结果:治疗前对照组和丹参组PT,APTT,TT和FIB测定值分别为:17.2±5.9s,50.3±5.1s,21.5±2.5s,1.7±1.2g/L和17.5±5.7s,50.1±5.8s,21.3±2.7s,1.7±1.0g/L,治疗后对照组和丹参组PT,APTT,TT和FIB测定值分别为:15.8±5.0s,47.2±5.3s,19.2±2.1s,1.8±1.3g/L和14.5±4.0s,44.2±5.6s,17.2±2.4s,2.0±1.5g/L.两组治疗前后PT,APTT,TT和FIB均有显著差异(P<0.05),但丹参组比对照组对PT,APTT,TT和FIB的改善更为明显(P<0.05).丹参组治疗期间出血发生率明显低于对照组(25%vs50%,P<0.05).结论:丹参注射液能够改善失代偿期肝硬化患者的凝血功能,降低临床出血率,提示丹参注射液治疗失代偿期肝硬化是安全有效的.AIM： To evaluate the effect of salvia miltiorrhiza （SM） injection on the coagulation function of patients with decompensated liver cirrhosis. METHODS： A total of 40 patients with decompensated liver cirrhosis were randomly and averagely divided into SM group and controls group. Besides comprehensive treatment, the patients in SM group also received SM injection for 2 wk. The indexes, including prothrombin time （PT）, activated partial thromboplastin time （APTT）, thrombin time （TT） and fibrinogen （FIB） level were examined before and after treatment. Moreover, bleeding complication was observed in the two groups. RESULTS： Before treatment, the values of PT, APTT and TT, and the level of FIB were 17.2 ± 5.9 s, 50.3 ± 5.1 s, 21.5 ± 2.5 s, 1.7 ±1.2 g/L in control group, and 17.5 ± 5.7 s, 50.1 ± 5.8 s, 21.3 ± 2.7 s, 1.7 ± 1.0 g/L in SM group, respectively. After treatment, the above markers were 15.8 ± 5.0 s, 47.2 ± 5.3 s, 19.2 ± 2.1 s, 1.8 ± 1.3 g/L in control group, and 14.5 ± 4.0 s, 44.2 ± 5.6 s, 17.2 ± 2.4 s, 2.0 ± 1.5 g/L in There were significant SM group, respectively. differences before and after treatment both in control group and SM group （P 〈 0.05）, and furthermore, marked differences also existed between the two groups after treatment （P 〈 0.05）. The incidence rate of bleeding complication was notably lower in SM group than that in control group （25% vs 50%, P 〈 0.05）. CONCLUSION： SM injection can improve the coagulation function and lower the rate of bleeding complication in patients with decompensated liver cirrhosis.

关 键 词：丹参 肝硬化失代偿 凝血功能 

分 类 号：R259[医药卫生—中西医结合]