糖尿病大鼠胃肠动力及肌间神经丛形态学改变  

Delayed gastrointestinal transit time and changes of ileum myenteric plexus in diabetic rats

作　　者：雷亚宁[1] 丁友梅[2] 钱旭[1] 郑裕勇 

机构地区：[1]温州医学院组织学与胚胎学教研室,325035 [2]温州医学院测试中心,325035 [3]温州市梧蜒三医院检验科

出　　处：《中华消化杂志》2006年第10期666-669,共4页Chinese Journal of Digestion

基　　金：湖北省自然科学基金(96J088);温州市科技局科学研究计划项目(Y2004A114)

摘　　要：目的了解糖尿病大鼠胃肠动力障碍时,肌间神经丛有无形态学异常并探讨胃肠功能异常的机制。方法30只大鼠分成对照组(10只)和糖尿病组(20只),糖尿病组用链脲佐菌素建立大鼠糖尿病模型,4个月后测定两组大鼠胃肠传输速率,并用酶组织化学方法观察回肠肌间神经丛内胆碱能和氮能神经的组织学改变。结果糖尿病组大鼠胃肠传输速率明显延迟,回肠肌间神经丛内胆碱能神经元密度明显降低(P＜0．01),氮能神经节和氮能神经元的密度均显著升高(P＜0．05和P＜0．01)。结论糖尿病大鼠小肠肌间神经丛内胆碱能神经减少,氮能神经增多,这可能是导致胃肠传输速率延迟的重要原因,由此引起小肠运动障碍。Objective To investigate the morphologic abnormalities of myenteric plexus in diabetic rats and to explore the mechanism of its effect on gastrointestinal motility. Methods Thirty rats were randomly divided into diabetic group and control group. Gastrointestinal transit time was measured and histologic changes of cholinergic and nitriergic nerves in ileum myenteric plexus were observed with enzymatic histochemistry. Results Four months after the establishment of the diabetic rats model, gastrointestinal transit time was found delayed comparing with control group, the density of cholinergic neurons in the ileum myenteric plexus was decreased （P〈0.01） and the densities of nitriergic ganglions and neurons were significantly increased comparing with control group （P〈0.05 and P〈0.01）. Conclusion Decrease of cholinergic nerves and increase of nitriergic nerves in the myenteric plexus of intestine is one of the mechanisms of delay gastrointestinal transit time in diabetic rats.

关 键 词：糖尿病 回肠 胆碱能神经 氮能神经 

分 类 号：R587.1[医药卫生—内分泌]