Synergism of hydrochlorothiazide and nitrendipine on reduction of blood pressure and blood pressure variability in spontaneously hypertensive rats  

作　　者：Ping HAN Zheng-xu CHU Fu-ming SHEN He-hui XIE Ding-feng SU 

机构地区：[1]Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

出　　处：《Acta Pharmacologica Sinica》2006年第12期1575-1579,共5页中国药理学报（英文版）

基　　金：Project supported by grants from the High Technology Research and Development(863)Program of China(2002 AA2Z346C);the Shanghai Foundation for Science and Technology Development(№03JC14001,04JC14001).

摘　　要：Aim： To investigate the possible synergism of hydrochlorothiazide and nitrendipine on reducing both blood pressure （BP） and blood pressure variability （BPV） in spontaneously hypertensive rats （SHR）. Methods： Seventy animals were randomly divided into seven groups. The doses were 5 and 10 mg/kg for nitrendipine, 10 and 20 mg/kg for hydrochlorothiazide and 10＋5, 20＋10 mg/kg, respectively, for the combination of these two drugs and 0.8% carboxym- ethylcellulose as control. The drugs were given via a catheter of gastric fistula. BP was then continuously recorded for 5 h from 1 h before drug administration to the end of 4th hour after drug administration, in conscious and freely moving rats. Results： The effects on both BP and BPV reduction of the combination of hydrochlorothiazide and nitrendipine were greater than the single drug in SHR. The two drugs possessed an obvious synergism on both systolic blood pressure （q=1.79 with small dose and q=1.23 with large dose） and systolic blood pressure variability reduction （q=1.79 with small dose and q=1.39 with large dose） in SHR. Conclusion： The present work clearly demonstrated that there was a synergistic effect between hydrochlorothiazide and nitrendipine in lowering and stabilizing BP in SHR.Aim： To investigate the possible synergism of hydrochlorothiazide and nitrendipine on reducing both blood pressure （BP） and blood pressure variability （BPV） in spontaneously hypertensive rats （SHR）. Methods： Seventy animals were randomly divided into seven groups. The doses were 5 and 10 mg/kg for nitrendipine, 10 and 20 mg/kg for hydrochlorothiazide and 10＋5, 20＋10 mg/kg, respectively, for the combination of these two drugs and 0.8% carboxym- ethylcellulose as control. The drugs were given via a catheter of gastric fistula. BP was then continuously recorded for 5 h from 1 h before drug administration to the end of 4th hour after drug administration, in conscious and freely moving rats. Results： The effects on both BP and BPV reduction of the combination of hydrochlorothiazide and nitrendipine were greater than the single drug in SHR. The two drugs possessed an obvious synergism on both systolic blood pressure （q=1.79 with small dose and q=1.23 with large dose） and systolic blood pressure variability reduction （q=1.79 with small dose and q=1.39 with large dose） in SHR. Conclusion： The present work clearly demonstrated that there was a synergistic effect between hydrochlorothiazide and nitrendipine in lowering and stabilizing BP in SHR.

关 键 词：blood pressure blood pressure variability HYDROCHLOROTHIAZIDE HYPERTENSION NITRENDIPINE spontaneously hypertensive rat 

分 类 号：R544.1[医药卫生—心血管疾病]