糖尿病患者胰岛素治疗前后唾液葡萄糖含量分析  

Glucose levels in saliva in patients with diabetes mellitus before and after insulin therapy

作　　者：孙慧斌[1] 钟德钰[1] 王颜刚[2] 徐龙强[3] 

机构地区：[1]青岛大学医学院附属医院口腔科,266003 [2]青岛大学医学院附属医院内分泌科,266003 [3]青岛大学医学院附属医院检验科,266003

出　　处：《实用口腔医学杂志》2006年第6期866-868,共3页Journal of Practical Stomatology

摘　　要：目的:研究糖尿病患者胰岛素治疗前后唾液中葡萄糖含量的改变,并观察唾液糖与血糖的关系。方法:实验组为40例糖尿病患者。收集糖尿病患者胰岛素治疗前后清晨非刺激状态下自然分泌的全唾液,进行葡萄糖含量分析,同时行空腹血糖分析。结果:治疗前患者的唾液葡萄糖含量为(2.081±0.287)mmol/L,高于治疗后的(1.571±0.193)mmol/L,二者有显著性差异(P<0.01);治疗前患者的唾液葡萄糖含量与血糖浓度有显著直线相关性(P<0.05);治疗后患者的唾液葡萄糖含量与血糖浓度无显著直线相关性(P>0.05)。结论:糖尿病患者唾液中的葡萄糖含量明显增加,说明唾液腺分泌功能发生改变;良好的胰岛素治疗不仅可以达到良好的血糖控制,还可以控制减少唾液葡萄糖的分泌量。Objective：To study the effect of insulin therapy on glucose concentration in saliva in patients with diabetes mellitus （DM） , and to study the relationship between blood glucose level and salivary glucose level. Methods： Glucose concentration in blood and in unstimulated mixed saliva was measured with Beckman SYNCHRON CX7 system in 40 DM patients before and after insulin therapy. Results：The average value（mmol/L） of salivary glucose concentration before and after insulin therapy was 2,081 ± 0. 287 and 1,571 ± 0. 193 respectively （ P 〈 0. 01 ）. Before insulin therapy linear regression of salivary glucose concentration was positively correlated with blood glucose concentration（P 〈 0.05）. After insulin therapy there was no correlation between salivary glucose concentration and blood glucose concentration. Conclusion：In DM patients high blood glucose concentration may result in high salivary glucose concentration, Effective glucose control can decrease the secretion of glucose in saliva.

关 键 词：糖尿病 唾液葡萄糖 血糖 胰岛素 

分 类 号：R587.1[医药卫生—内分泌]