水蛭注射液合肾上腺皮质激素治疗原发性肾病综合征疗效观察  

Clinical Control Observation on Treament of Primary Nephrotic Syndrome with Adrenocortical Hormone and the Shuzhi Injection

作　　者：吴金玉[1] 史伟[1] 黄雪霞[1] 谢丽萍[1] 唐宇[1] 

机构地区：[1]广西中医学院第一附属医院肾内科,广西南宁530023

出　　处：《辽宁中医杂志》2006年第11期1420-1421,共2页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:观察水蛭注射液合肾上腺皮质激素治疗原发性肾病综合征的临床疗效。方法:116例原发性肾病综合征患者随机分成两组,对照组54例予肾上腺皮质激素治疗,治疗组62例予水蛭注射液合肾上腺皮质激素治疗,观察两组治疗前后尿蛋白、肾功能、血浆白蛋白、血脂、血液流变学变化及两组复发率和不良反应发生率的差异。结果:治疗组总有效率88.7%,高于对照组的70.4%(P<0.05);两组在尿蛋白、肾功能、血浆白蛋白、血脂及血液流变学等方面相比,差异有统计学意义(P<0.05或P<0.01);治疗组复发率与不良反应发生率分别为8%和17.74%,低于对照组的20.3%和42.5%(P<0.05)。结论:水蛭注射液合肾上腺皮质激素比单纯肾上腺皮质激素治疗原发性肾病综合征疗效好。Objective： To observe the clinical therapeutic effect on primary nephrotic syndrome with adrenocortical hormone（ACH） and the shuzhi injection. Methods ：116 cases were randomly divided into two group the treatment group of 62 treated with ACH and the shuzhi injection and the control group of 54 cases only with ACH. Observations were made on the changes of urinary protein,renal function, plasma albumin, blood fat and blood rheology before and after the treatment and on the differences of recurrence rate and the incidence rate of adverse reaction between the two groups. Results： The total effective rate in the treatment group reached 88. 7% ,while the control group 70.4% （ P 〈0.05 ）. There were obviously changes between the two groups on urinary protein,renal function,plasma albumin,blood fat and blood theology （ P 〈0.05 orP 〈0.01 ）. The recurrence rate（ 8% ）and the incidence rate of adverse reaction （ 17.74% ） in the treatment group were lower than those with （20.3%） and （42.5%） respectively（ P 〈 0.05）. Conclusions ：The better therapeutic effect can be achieved for primary nephrotie syndrome through the application of beth ACH and the shuzhi injection than the single use of ACH.

关 键 词：原发性肾病综合征 水蛭注射液 肾上腺皮质激素 

分 类 号：R692[医药卫生—泌尿科学]