Pterocaryquinone, a Novel Naphthoquinone Derivative from Pterocarya tonkinesis  

作　　者：刘红兵 蔡兵 崔承彬 颐谦群 赵庆春 管华诗 

机构地区：[1]Key Laboratory of Marine Drugs, MEC, Marine Drug and Food Institute, Ocean University of China, Qingdao, Shandong 266003, China [2]Beijing Institute of Biomedicine, Beijing 100091, China [3]Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China

出　　处：《Chinese Journal of Chemistry》2006年第12期1683-1686,共4页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China for Distinguished Young Scholars （No. 39825126）, the 973-project from Ministry of Science and Technology （No. 1998051113）, and the Fund for Cheung Kong Scholar from the Cheung Kong Scholars Program of Minis- try of Education of China.Acknowledgments We thank Prof. Q. Sun and Mrs. G. Qu, both of Shenyang Pharmaceutical University, China, for their contributions on the collection and identification of the plant materials. Dr. H. 0sada, head of the Antibiotics Laboratory, the Institute of Physical and Chemical Re- search （RIKEN）, Japan, kindly provided the tsFT210 cell line.

摘　　要：Pterocaryquinone, a novel 1,4-naphthoquinone derivative, was isolated from Pterocarya tonkinesis and its structure was elucidated by spectroscopic methods. Pterocaryquinone is a new dimeric 1,4-naphthoquinone derivative having a pentacyclic skeleton with two five-membered carbon rings, which provided a novel structural skeleton for 1,4-naphthoquinone derivatives and showed apoptosis-inducing activity toward mouse cancer tsFT210 cells.Pterocaryquinone, a novel 1,4-naphthoquinone derivative, was isolated from Pterocarya tonkinesis and its structure was elucidated by spectroscopic methods. Pterocaryquinone is a new dimeric 1,4-naphthoquinone derivative having a pentacyclic skeleton with two five-membered carbon rings, which provided a novel structural skeleton for 1,4-naphthoquinone derivatives and showed apoptosis-inducing activity toward mouse cancer tsFT210 cells.

关 键 词：Pterocarya tonkinesis NAPHTHOQUINONE pterocaryquinone chemical structure APOPTOSIS 

分 类 号：R284[医药卫生—中药学]