红花干预特发性水肿微循环障碍的实验研究  

Experimental research for Honghua injection in anti-microcirculation disturbance in patients with idiopathic edema

作　　者：李荣[1] 张健[2] 梁海峰[1] 赵九安[1] 

机构地区：[1]河北北方学院,河北省张家口市075029 [2]河北建筑工程学院

出　　处：《河北医药》2006年第10期908-909,共2页Hebei Medical Journal

基　　金：河北省科学技术研究与发展指导计划(No:052761691)

摘　　要：目的观察特发性水肿患者甲襞微循环的变化,探讨红花注射液对特发性水肿的治疗作用及微循环机制。方法特发性水肿患者52例,应用红花注射液进行治疗;健康女性60例作为对照组。采用微循环显微镜,于治疗前后常规检查左手第四指甲襞第一排管袢,按田牛加权积分法对16项指标综合定量分析,判断疗效和甲襞微循环的变化。结果特发性水肿组治疗前均出现甲襞微循环障碍,表现为轻度或中度异常。治疗后水肿症状有不同程度的缓解或消失,总有效率为86.5%;甲襞微循环障碍明显改善,由治疗前的中度异常恢复到大致正常,总积分值由治疗前的4.478±0.813降为1.591±0.725(P<0.01)。结论红花注射液对特发性水肿具有明显的疗效,其机制与改善微循环障碍有关。Objective To investigate the changes of nailfold microcirculation in idiopathic edema and study the therapeutic effect of Honghua injection in patients with idiopathic edema and its curative mechanism for microcirculation. Methods The observation for the nailfold microcirculation was conducted in the therapeutic group before and after treatment （52 patients with idiopathic edema were treated by Honghua injection） and normal group treated by routine method. With the help of the microscope, 16 indexes were analysed by Tian＇s Multiple Quantitative Evaluation Method of Nailfold Microcirculation. The clinical effect and changes of nailfold microcirculation were observed and recorded carefully. Results Before the treatment, there was obvious microcirculation disturbance in patients with idiopathic edema, which was in light or moderate abnormality. After treatment, the symptoms of edema disappeared or were relived with different degrees and the total effective rate was 86.5%. Improvement for microcirculation disturbance with idiopathic edema was evident. The result showed that all parameters decreased obviously compared with that of pre-treatment, restoring to basically normal from medium abnormality before treatment. The total value reduced to 1.591±0.725 from 4.478±0.813 （P 〈 0.01）. Conclusion Honghua injection has a good curative effect on idiopathic edema and its mechanism might be related to improvement of microcirculation.

关 键 词：特发性水肿 红花注射液 甲襞 微循环 

分 类 号：R512.602[医药卫生—内科学]