“聪耳药膜”治疗鼓膜穿孔的疗效及愈合过程的超微结构的观察  

Therapeutic effect of "healing-promoting medicinal membrane" on tympanic membrane perforation and ultrastructural observation on tympanic membrane undergoing perforation healing

作　　者：李云英[1] 刘忠钰[1] 袁小红[1] 许耀东[2] 吴义芳[2] 

机构地区：[1]广州中医药大学第二临床医学院耳鼻咽喉科,广州510120 [2]广州中山大学

出　　处：《中国中西医结合耳鼻咽喉科杂志》2006年第6期357-359,共3页Chinese Journal of Otorhinolaryngology in Integrative Medicine

基　　金：国家中医药管理局资助项目(编号97A206)

摘　　要：目的探讨“聪耳药膜”治疗鼓膜穿孔的疗效及其作用机制。方法98例(102耳)鼓膜穿孔患者,按1∶1随机分为实验组48例(52耳)以中药制剂“聪耳药膜”补贴鼓膜穿孔;和对照组50例(50耳)以棉片补贴鼓膜穿孔。对比观察鼓膜穿孔愈合情况。另以20只健康成年豚鼠,随机分为两组制作鼓膜穿孔,对照组不作补贴,中药膜组用中药膜补贴穿孔。结果聪耳药膜实验组的痊愈率为21.2%,总有效率为88.5%;对照组的痊愈率为8.0%,总有效率为54.0%,(P<0.05),两组疗效差异有显著性意义。豚鼠鼓膜穿孔造模术后1月、2月透射电镜观察,聪耳药膜组及造模对照组的穿孔均已愈合,但中药膜组的组织修复形态较对照组为优。结论聪耳药膜治疗鼓膜穿孔有满意的临床疗效,为安全有效的中药制剂。Objective To investigate the therapeutic effect of ＂healing-promoting medicinal membrane＂ （HPMM） on tympanic membrane perforation and associated mechanisms responsible for its healing process. Methods Ninety-eight cases （102 ears） with tympanic membrane perforation were randomly divided into 2 groups at a ratio of 1 ： 1, with 48 cases （52 ears） in treating group （TG） and 50 patients （50 ears） in controlling one （CG）. The cases of TG were treated by HPMM, made from botanical medicines, adhered to the tympanic membrane with perforation, and those of CG were treated only by a piece of cotton adhered to the tympanic membrane with perforation in the same way as mentioned above. Then, the therapeutic effects were compared between them by the end of therapeutic course, indicated only by the healing condition of tympanic membrane perforation. Furthermore, 20 guinea pigs were taken to prepare the model of tympanic membrane perforation and undergo treating process in the same way as that for clinical trial, with 2 groups being randomly divided and 2 different treating procedures given respectively. By the end of therapy, tympanic membrane samples were taken from the animals to do uhrastructural observation in a regular way to see the changes associated with the healing process of tympanic membrane perforation. Results The curative rate was 21.2 % in TG, with a total effective rate of 88.5 %, and it was only 8.0 % in CG, with a total effective rate of 54.0 %. There was a significant difference between the 2 groups in the effective rates （P 〈 0.05）. All the experimental animals were seen with their tympanic membrane perforation healed within 1 to 2 months following modeling in either group. However, the healing process in TG was superior to that of CG as confirmed at the ultrastructural level. Conclusion HPMM holds significantly therapeutic effect for the treatment of tympanic membrane perforation.

关 键 词：中药药膜 鼓膜穿孔 疗效 

分 类 号：R285.5[医药卫生—中药学]