PPARγ2基因C1431T多态与肥胖的关联研究  

作　　者：赵艳红[1] 丛祥凤[1] 陈曦[1] 

机构地区：[1]中国医学科学院 中国协和医科大学 阜外心血管病医院生化研究室,北京100037

出　　处：《中国分子心脏病学杂志》2003年第3期140-143,共4页Molecular Cardiology of China

摘　　要：目的 研究中国汉族人群中γ_2-过氧化酶体增殖剂激活受体(Peroxisome proliferative activated receptor γ-2,PPARγ2) 基因C1431T多态性与肥胖的关系 方法 从北京地区选取肥胖病例及对照共574例,病例、对照均是287例。所有研究对象记录其病史、体检等临床资料及吸烟、饮酒等流行病学资料,采用PCR-RFLP检测各组PPARγ2基因C1431T多态基因型并统计各组的多态性频率 结果 C1431T多态性位点的基因型C/C、C/T和T/T的频率分別为53.7％(n=308),43.0％(n=247)和3.3％(n=19),C1431和T1431等位基因频率分别是0.752和0.248,基因型分布符合Hardy-Weinberg平衡定律 肥胖组和对照组的PPARγ2基因C1431T多态基因型频率及等位基因频率无显著差别,C1431T多态与肥胖相关的数量表型没有显著相关性。结论 PPARγ2基因C1431T多态与中国汉族人群的肥胖发生无显著相关性。Objective To investigate the relationship between PPARγ2 gene polymorphism and obesity in Chinese Han population. Methods The technology of polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was used to detect genotype of PPARγ2 C1431T. The study group included 287 obesity patients and 287 controls. Results The frequency of PPARγ2 C1431T genotype and allele had no significant difference between obesity and control subjects （P〉0.05）. The frequency distribution of this polymorphism was consistent with the law of Hardy-Weinberg. C1431T of PPARγ2 had no association with any of obesity-related quantitative traits （P〉0.05）. Conclusion The polymorphism of PPARγ2 C1431T may he not a genetic independent risk factor in obesity of Chinese Han population.

关 键 词：PPARΓ2基因 多态性 肥胖 

分 类 号：R589[医药卫生—内分泌]