糖尿病与冠心病人QT间期及离散度变化的相关性研究  

The study of relationship between QT interval and dispersion in diabetic and coronary heart disease patients

作　　者：李绍生[1] 刘澎涛 李兰荪[1] 杨杰 

机构地区：[1]第四军医大学西京医院心内科,西安710032 [2]解放军第518医院,西安710043

出　　处：《中国分子心脏病学杂志》2003年第3期149-151,共3页Molecular Cardiology of China

摘　　要：糖尿病和冠心病人的QTc和QTd明显长于非患病病者,可为预测心血管事件的发生提供依据。方法:采用病例—病例对照的研究方法,将130例糖尿病、冠心病病人分为冠心病组(G1)53例、糖尿病组(G2)47例、糖尿病合并冠心病组(G3)30例,对比QTc和QTd的变化及其与糖尿病和冠心病的相关性。结果:G3组病人的QTc和QTd较G1、G2组明显延长(P=0.010和0.017),相关分析结果显示QTd与QTc明显相关(R=0.252 P=0.004),糖尿病或CHD病人的QTc与是否合并CHD或糖尿病独立相关(?=0.368和0.336 P=0.007和0.046)。结论:糖尿病对心肌电活动的影响与心肌缺血引起的相近,二者合并出现后加重了心肌电活动的不稳定性。Patients with DM or CHD had higher mean adjusted values of QTc and QTc dispersion which can predict cardic and vascular affairs. Method： A case-case control study was designed. 130 patients were assigned into three groups： CHD group （G1 n=53）, DM group （G2 n=47）, CHD and DM group （G3 n= 30） ,compared change of QTc and QTd with each other, analysed the relationship between them. Resuhs：G3 had a higher QTc and QTc dispersion than G1, G2 （P=0.010 and 0.017） .Regression analysis suggested that QTd and QTc duration were significantly correlated （R=0.252, P= 0.004） , QTc was independently associated with DM or CHD in CHD or DM patients ？：0.368 and 0.336 P=0.007 and 0.046）o Conclusion： There was an equal effect on electronic action of myocardium in patients with DM compared with CHD, and a higher injury if they existed at the same time.

关 键 词：糖尿病 冠心病 QT间期 QT间期离散度 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]