细胞粘附的压电生物传感芯片研究  

The Research of Cells′ Adhesion by Piezoelectric Biosensor Chip

作　　者：莫志宏[1] 高小丽[1] 吴永强[2] 韦晓兰[3] 

机构地区：[1]重庆大学化学化工学院,重庆400044 [2]四川理工学院材料与化学工程系,四川自贡643033 [3]重庆工商大学环境与生物工程学院,重庆400067

出　　处：《压电与声光》2006年第6期719-721,724,共4页Piezoelectrics & Acoustooptics

基　　金：国家十五科技攻关基金资助项目(03c26215100252)

摘　　要：细胞粘附研究因其重要价值日益成为生命科学和组织工程领域的研究热点。运用压电传感技术研究细胞粘附行为具有实时、高灵敏及动态的独特优势,为细胞粘附的研究提供了更为科学全面的信息。该文就肝癌细胞粘附的压电生物传感芯片研究进行了实验探讨和动力学分析,以及扫描电镜(SEM)和双胰酶消化法(DTA)双向实验验证和声阻抗模型理论分析,建立了压电生物传感芯片研究细胞粘附的新方法。The research on cells adhesion became more and more hot in biomedical engineering and tissue engineering field. Because of advantages as real time, high-sensitivity and continuty, the piezoelectric biosensor chip will be a good tool for the study of cells adhesion. The technique will provide more scientific and all around infurmation on cells adhesion. Some experiments were done tu study liver cancer cells adhesion behavior by Piezoelectric biosensor chip, as well as the analysis of the dynamic process and acoustic impedance concept theory. The new method-piezoelectric biosensor chip was build for the research of cells adhesion after tested by scanning electron microscope （SEM） and double trypsin assay（DTA ）.

关 键 词：细胞粘附 压电 生物传感芯片 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置]