硝苯啶对妊高征孕妇微循环的影响  

TheEffectofNifedipineontheMicrocirculationinPregnancy┐InducedHypertension

作　　者：郝翠芳[1] 于小玲[1] 李法升[1] 王宝娃 赵子文 石增立 

机构地区：[1]滨州医学院附属医院妇产科

出　　处：《中华妇产科杂志》1996年第11期673-675,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的：观察硝苯啶对妊高征孕妇微循环的影响。方法：采用微循环显微仪观察３０例正常孕妇和７６例妊高征孕妇，舌下含化硝苯啶２０ｍｇ前后甲襞微循环的变化。结果：硝苯啶有增加微循环血流速度、减轻红细胞聚集和扩张微血管管径的作用。服药前后轻、中度妊高征孕妇甲襞微循环积分比较，差异有显著性（Ｐ＜０．０５）。重度妊高征孕妇甲襞微循环积分服药前后比较，差异无显著性（Ｐ＞０．０５）。Objectives:Tostudytheefectsofnifedipineonthemicrocirculationinpregnancy-in-ducedhypertension(PIH).Methods:Weobservedthemicrocirculationinnailfoldof30normalpreg-nantwomenand76casesofPIH.20mgnifedipinewasgivenandnailfoldmicrocirculationwasob-servedafter30minites.Results:Nifedipineincreasedthevelocityofbloodflow,reducedtheaggre-gationoferythrocytes,anddilatedcapilaries.Aftertheadministrationofnifedipine,thetotalscoreofthenailfoldmicrocirculationdecreasedsignificantlyinmildandmoderatePIH(P<0.05),butnomarkeddiferencewasobservedinseverePIHcases(P>0.05).Conclusion:Thedisorderofthemi-crocirculationofPIHcanbeimprovedbynifedipine.

关 键 词：硝苯地平 妊娠并发症 高血压 微循环 

分 类 号：R714.253[医药卫生—妇产科学]