苄羟麻黄碱治疗早产的临床观察  

TreatmentofPretermLaborwithRitodrine

作　　者：朱宝馀[1,2] 符玉良[1,2] 

机构地区：[1]广州市第一人民医院妇产科 [2]广州市妇婴医院妇产科

出　　处：《中华妇产科杂志》1996年第12期721-723,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的：探讨β２－肾上腺素能受体兴奋剂苄羟麻黄碱抑制子宫收缩，治疗早产的临床效果。方法：对１２６例先兆早产孕妇随机分为两组，分别静脉滴注苄羟麻黄碱或硫酸镁。采用达到有效抑制宫缩的最低浓度，适时停药，病情反复则间歇多次应用。结果：苄羟麻黄碱首次用药达有效抑制宫缩的显效时间为２．３３±０．６３小时，用药总累计时间为９．３８±３．８８天；延长孕期４．８１±２．８３周；足月分娩率７３．４４％；均极显著优于硫酸镁组（Ｐ分别＜０．００１、０．００５、０．０１）。尚未发现严重毒副反应。结论：苄羟麻黄碱抑制宫缩作用强、显效快，治疗早产安全。Objective:toinvestigatethetreatmentofpretermlaborwiththeβ-adrenergicagonistritodrine.Methods:126womenwithpretermlaborwererandomlyassignedtointravenousinfusionofritodrineormagnesiumsulfatetreatment.Usingminimalefectivedosageforinhibitionofuterineactivity,terminatingtherapyontime,andrepeatingthei.v.infusionifcontractionrestartedwerethestrategyfortreatment.Results:Ritodrinewassignificantlymoreeffectivebothinthetreatingperiodforsuppressionofcontraction(2.33±0.63hrforinitiationofinhibitinguterineactivity,9.38±3.88daysofaccumulativetreatingperiod)andprolongationofgestation(4.81±2.83wks)thanthatofthemagnesiumsulfate(P<0.001,0.005and0.01respectively),andhadatermlaborof73.44%.Therewasnoseriouscardiacandpulmonarycomplicationsintheritodrinegroup.Conclusion:Thepresentstudyhasshownthatritodrineasatocolyticagentishighlyefectiveforthemanagementofpretermlaborandrelativesafeformotherandfetus.

关 键 词：麻黄碱 硫酸镁 早产 药物疗法 

分 类 号：R714.210.5[医药卫生—妇产科学]