局部亚低温状态下尼莫地平治疗弥漫性轴索损伤的疗效研究  

The research on the efficacy of Nimodipine in treating diffues axonal injury under the local subhypothem

作　　者：谭立宇[1] 沈建忠[1] 王继斌[1] 肖瑾瑛[1] 

机构地区：[1]井冈山学院附属医院神经外科

出　　处：《江西医药》2006年第10期725-727,共3页Jiangxi Medical Journal

摘　　要：目的观察联合使用局部亚低温及尼莫地平治疗弥漫性轴索损伤的临床疗效。方法62例弥漫性轴索损伤患者随机分为治疗组和对照组各31例。治疗组患者在常规治疗基础上入院30min即应用尼莫同注射液微量泵持续静脉输入,10～13μg/kg.h,24h持续,连续用药10～14d。同时联合局部亚低温治疗,使脑温控制在33～35℃,治疗时间为5～7d,对照组按常规治疗,治疗2周后监测格拉斯哥昏迷评分及3个月后格拉斯哥预后分级进行评估及统计。结果治疗组和对照组在格拉斯哥评分,预后分级比较差异均有显著性(P<0.05)。结论局部亚低温状态下尼莫同治疗弥漫性轴索损伤疗效显著。Objective To observe the efficacy of treating diffues axonal injury with local subhypothem and Nimodipine. Methods 62 patients with diffues axonal injury were randomly divided into two groups,31 patients in the observed group, besides accepting traditional treatment were treated intravenous sustained injection with nimodipine by intellegent-controled microscale pump（10～13μg/kg.h , 24 hours continous inject by intravenous） after 30 minutes sent to hospital and continually inject for 10～14 days. At the same time, with local subhypothem to control the temperature of the brain within 33 to 35℃ for 5 to 7 days, And another group were treated with traditional treatment. Evaluated statistically by monitoring GCS after 2 weeks treatment and GOS after 3 months. Results The difference of GCS and GOS between two groups were noticeable （P 〈0.05）. Conclusion The efficacy of treating diffues axonal injury with local subhypothem and nimodipine is outstanding.

关 键 词：弥漫性轴索损伤 尼奠地平 亚低温治疗 

分 类 号：R651.15[医药卫生—外科学]