冠心病患者介入治疗前后血小板CD41、CD62p的表达  

Expression of Platelet Surface Glycoprotein CD 41 and CD 62p in Patients with Coronary Heart Disease Treated by Percutaneous Coronary Intervention

作　　者：李俊勇[1] 孙智敏[2] 齐晓勇[3] 王燕舞[1] 

机构地区：[1]白求恩军医学院内科教研室,石家庄050081 [2]河北科技大学理学院,石家庄050018 [3]河北省人民医院心内科,石家庄050071

出　　处：《白求恩军医学院学报》2006年第4期195-196,共2页Journal of Bethune Military Medical College

摘　　要：目的探讨经皮冠状动脉介入治疗(PCI)前后血小板CD41、CD62p变化及其临床意义。方法98例行PCI的患者分为不稳定型心绞痛组(50例)和稳定型心绞痛组(48例)。对照组40例为冠状动脉造影正常患者。流式细胞仪测定血小板CD41、CD62p的表达。结果CD41、CD62p水平在PCI术后即刻较术前有显著性下降,随后逐渐升高,术后4h达到峰值。不稳定心绞痛组CD41、CD62p在术前及峰值水平均较稳定组显著升高。对照组患者CD41、CD62p水平在冠状动脉造影前后无显著性变化。结论血小板活性在PCI前后有动态改变,血小板激活状态与斑块稳定性密切相关。Objective To study CD 41 and CD 62p changes and their clinical significance in patients with coronary heart disease（CHD） who were treated with pereutaneous coronary intervention （PCI）. Methods The study group was comprised of 98 consecutive patients who underwent PCI, of which 50 patients unstable angina pectoris and 48 patients were had stable angina pectoris. At the same time 40 angiographically normal patients were as controls. The expression of CD 41 and CD 62p was examined by flow cytometry. Results Post-procedural levels of CD 41 and CD 62p showed a significant decrease compared with preprocedural levels,then tended to increase,and arrived at the peak at 4 h after PCI. Preprocedural and peak levels of CD 41 and CD 62p were significantly higher in patients with unstable angina pectoris than those in patients with stable angina pectoffs. Conclusion The activity of platelet showed a dynamic change before and after PCI, and activation of platelet was positively related to stability of plaque.

关 键 词：冠心病 经皮冠状动脉介入治疗 CD 41 CD 62p 

分 类 号：R541.4[医药卫生—心血管疾病]