实验性甲状腺功能低下大鼠脑神经细胞超微结构变化  

Changes of ultrastructure in brain neurons of experimental hypothyroidal rats

作　　者：王淑秋[1,2] 陶佳南[1,2] 孟丹[1,2] 秦文波[1,2] 陈莉明[1,2] 赵金[1,2] 

机构地区：[1]佳木斯医学院病生教研室 [2]佳木斯医学院附属医院

出　　处：《中国地方病学杂志》1996年第4期219-220,共2页Chinese Jouranl of Endemiology

摘　　要：观察了甲基硫脲嘧啶（ＭＴＵ）复制甲低大鼠脑神经细胞超微结构变化。结果表明实验组脑神经细胞粗面内质网变性，部分核蛋白体脱失和游离，线粒体肿胀、嵴减少或消失，核膜边缘不清。由此可见甲低通过脑神经细胞结构改变，导致中枢神经系统损伤和发育障碍。The change of ultrastructure of the neurons in MTU induced hypothyroid rat was observed with the electron microscopy.Ourresults showed that dilatation of granular endoplasmic reticulum,ribosomal detachment and isolation cristae occurred.Swellingof mitochondria occurred,and nucleus membrane was not clear.These data suggested that the hypothyroidism brings about changes of structure in the neurons and causes the injury and retard development of the central nervous system

关 键 词：甲状腺机能减退 脑神经细胞 超微结构 

分 类 号：R581.2[医药卫生—内分泌]